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  • 产品名称：TumorNecrosisFactor(TNF)(AA77-233)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
TumorNecrosisFactor(TNF)(AA77-233)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 18.2 kDa. The protein migrates as 18.2 kDa under reducing (R) condition (SDS-PAGE).
Purity >95 % as determined by SDS-PAGE.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Tumor necrosis factor alpha (TNFα) is a cytokine produced primarily by monocytes and macrophages. It is found in synovial cells and macrophages in the tissues.The primary role of TNFα is in the regulation of immune cells. TNFα is able to induce apoptotic cell death, to induce inflammation, and to inhibit tumorigenesis and viral replication. Dysregulation of TNFα production has been implicated in a variety of human diseases, including major depression, Alzheimer's disease and cancer. Recombinant TNFα is used as an immunostimulant under the INN tasonermin. TNFα can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.
Molecular Weight 18.2 kDa
Gene ID 18, 17
UniProt P01375
Research Area Virology, Cancer, Inflammation
Pathways NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Storage -20 °C
Supplier Images
SDS-PAGE (SDS) image for Tumor Necrosis Factor (TNF) (AA 77-233) (Active) protein (His tag) (ABIN4949149) Human TNF-alpha, His Tag on SDS-PAGE under reducing (R) condition. The gel was staine...
Binding Studies (Bind) image for Tumor Necrosis Factor (TNF) (AA 77-233) (Active) protein (His tag) (ABIN4949149) Immobilized Human TNF-alpha, His Tag (Cat# TNA-H5228) at 0.2 μg/mL (100 μl/well) can ...