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  • 产品名称：S100CalciumBindingProteinA13(S100A13)(AA1-98)(Active)Protein

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  • 产品厂商：ACROBiosystems
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简单介绍：
S100CalciumBindingProteinA13(S100A13)(AA1-98)(Active)Protein
详情介绍：
Characteristics This protein carries no "tag". The protein has a calculated MW of 11.5 kDa. The protein migrates as 13 kDa under reducing (R) condition (SDS-PAGE).
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background S100 calcium-binding protein A13 (S100A13) is a member of the S-100 family. S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100 % soluble in ammonium sulfate at neutral pH . Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from the neural crest, chondrocytes, macrophages, dendritic cells, etc. S100A13 plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. S100A13 is required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine.
Molecular Weight 11.5 kDa
UniProt Q99584
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 150 mM NaCl, pH 8.0
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for S100 Calcium Binding Protein A13 (S100A13) (AA 1-98) (Active) Protein (ABIN2181713) Human S100A13, Tag Free on SDS-PAGE under reducing (R) condition. The gel was stained...
Background publications Cao, Yan, Yang, Zu, Wen, Zhong: "Effect of human S100A13 gene silencing on FGF-1 transportation in human endothelial cells." in: Journal of the Formosan Medical Association = Taiwan yi zhi, Vol. 109, Issue 9, pp. 632-40, 2010 (PubMed).

Small, Kovalenko, Soldi, Mandinova, Kolev, Trifonova, Bagala, Kacer, Battelli, Liaw, Prudovsky, Maciag: "Notch activation suppresses fibroblast growth factor-dependent cellular transformation." in: The Journal of biological chemistry, Vol. 278, Issue 18, pp. 16405-13, 2003 (PubMed).

Mandinova, Soldi, Graziani, Bagala, Bellum, Landriscina, Tarantini, Prudovsky, Maciag: "S100A13 mediates the copper-dependent stress-induced release of IL-1alpha from both human U937 and murine NIH 3T3 cells." in: Journal of cell science, Vol. 116, Issue Pt 13, pp. 2687-96, 2003 (PubMed).

Wicki, Schäfer, Erne, Heizmann: "Characterization of the human and mouse cDNAs coding for S100A13, a new member of the S100 protein family." in: Biochemical and biophysical research communications, Vol. 227, Issue 2, pp. 594-9, 1996 (PubMed).