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  • 产品名称：LeukocyteImmunoglobulin-LikeReceptor,SubfamilyB(WithTMandITIMDomains),Member4(L

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  • 产品厂商：ACROBiosystems
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简单介绍：
LeukocyteImmunoglobulin-LikeReceptor,SubfamilyB(WithTMandITIMDomains),Member4(LILRB4)(AA22-259)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 52.9 kDa. The protein migrates as 53-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4) is also known as CD85 antigen-like family member K (CD85K), Immunoglobulin-like transcript 3 (ILT-3), Leukocyte immunoglobulin-like receptor 5 (LIR-5), Monocyte inhibitory receptor HM18, which belongs to the leukocyte immunoglobulin-like receptor (LIR) family. LILRB4 / CD85K contains 2 Ig-like C2-type (immunoglobulin-like) domains. CD85K is detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells. LILRB4 / CD85K is receptor for class I MHC antigens. CD85K recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles, involved in the down-regulation of the immune response and the development of tolerance. LILRB4 interferes with TNFRSF5-signaling and NF-kappa-B up-regulation and inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
Molecular Weight 52.9 kDa
UniProt Q8NHJ6
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.0
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 4 (LILRB4) (AA 22-259) (Active) protein (Fc Tag) (ABIN2181477) Human LILRB4, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained ov...
Background publications Chang, Ciubotariu, Manavalan, Yuan, Colovai, Piazza, Lederman, Colonna, Cortesini, Dalla-Favera, Suciu-Foca: "Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4." in: Nature immunology, Vol. 3, Issue 3, pp. 237-43, 2002 (PubMed).

Cella, Döhring, Samaridis, Dessing, Brockhaus, Lanzavecchia, Colonna: "A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing." in: The Journal of experimental medicine, Vol. 185, Issue 10, pp. 1743-51, 1997 (PubMed).