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  • 产品名称：Interleukin20Receptorbeta(IL20RB)(AA30-230)(Active)protein(FcTag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
Interleukin20Receptorbeta(IL20RB)(AA30-230)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 49.1 kDa. As a result of glycosylation, the protein migrates as 50 kDa under reducing (R) condition, and 100 kDa under non-reducing (NR) condition (SDS-PAGE).
Purity >90 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: Measured by its binding ability in a functional ELISA. When Recombinant Human IL-19 protein is present at 0.2 μg/mL, the concentration of rhIL20RB Fc Chimera that produces 50% of the optimal binding response is approximately 5-50 ng/mL.
Background Interleukin-20 receptor subunit beta (IL20RB) is also known as IL-20R2, DIRS1, which belongs to the type II cytokine receptor family. IL20RB / IL-20R2 contains two fibronectin type-III domains. IL20RB / IL-20R2 is widely expressed with highest levels in skin and testis. IL20RB can be fused with IL20RA or IL22RA1 forming heterodimer. The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24.
Molecular Weight 49.1 kDa
UniProt Q6UXL0
Pathways Regulation of Leukocyte Mediated Immunity
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Interleukin 20 Receptor beta (IL20RB) (AA 30-230) (Active) protein (Fc Tag) (ABIN2181369) Interleukin 20 Receptor beta (IL20RB) (AA 30-230) (Active) protein (Fc Tag)
Background publications Habib, Senadheera, Weinberg, Kaushansky: "The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3." in: Biochemistry, Vol. 41, Issue 27, pp. 8725-31, 2002 (PubMed).

Parrish-Novak, Xu, Brender, Yao, Jones, West, Brandt, Jelinek, Madden, McKernan, Foster, Jaspers, Chandrasekher: "Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions." in: The Journal of biological chemistry, Vol. 277, Issue 49, pp. 47517-23, 2002 (PubMed).

Blumberg, Conklin, Xu, Grossmann, Brender, Carollo, Eagan, Foster, Haldeman, Hammond, Haugen, Jelinek, Kelly, Madden, Maurer, Parrish-Novak, Prunkard, Sexson, Sprecher, Waggie, West, Whitmore, Yao et al.: "Interleukin 20: discovery, receptor identification, and role in epidermal function. ..." in: Cell, Vol. 104, Issue 1, pp. 9-19, 2001 (PubMed).

Dumoutier, Leemans, Lejeune, Kotenko, Renauld: "Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 7, pp. 3545-9, 2001 (PubMed).