产品详情
查看大图

  • 产品名称：Cadherin1,Type1,E-Cadherin(Epithelial)(CDH1)(AA23-621)(Active)protein(Histag)

  • 产品型号：
  • 产品厂商：ACROBiosystems
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Cadherin1,Type1,E-Cadherin(Epithelial)(CDH1)(AA23-621)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 67 kDa. The protein migrates as 67 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >90 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells, cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-1 (CDH1) is also known as epithelial cadherin (E-cadherin), CD_antigen (CD324), Uvomorulin (UVO) ECAD and CDHE, CDH1 / CD324 contains 5 cadherin domains. CDH1 / CD324 / ECAD is expressed in non-neural epithelial tissues. CDH1 / E-CAD is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells and has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad promotes non-amyloidogenic degradation of Abeta precursors and has a strong inhibitory effect on APP C99 and C83 production. Defects in CDH1 / CD324 / ECAD are the cause of hereditary diffuse gastric cancer (HDGC).
Molecular Weight 67 kDa
UniProt P12830
Pathways Sensory Perception of Sound, Cell-Cell Junction Organization, Tube Formation
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
Supplier Images
SDS-PAGE (SDS) image for Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) (AA 23-621) (Active) protein (His tag) (ABIN2180987) Human E-Cadherin, His Tag on SDS-PAGE under reducing (R) condition. The gel was stain...
Background publications Shojaei, Wu, Zhong, Yu, Liang, Yao, Blanchard, Bais, Peale, van Bruggen, Ho, Ross, Tan, Carano, Meng, Ferrara: "Bv8 regulates myeloid-cell-dependent tumour angiogenesis." in: Nature, Vol. 450, Issue 7171, pp. 825-31, 2007 (PubMed).

Meng, Han, Zhao, Huang, Si, Wu, Mu: "Induction of the LRP16 gene by estrogen promotes the invasive growth of Ishikawa human endometrial cancer cells through the downregulation of E-cadherin." in: Cell research, Vol. 17, Issue 10, pp. 869-80, 2007 (PubMed).

Agiostratidou, Muros, Shioi, Marambaud, Robakis: "The cytoplasmic sequence of E-cadherin promotes non-amyloidogenic degradation of A beta precursors." in: Journal of neurochemistry, Vol. 96, Issue 4, pp. 1182-8, 2006 (PubMed).

Yoon, Ku, Yang, Kim, Park, Park: "Germline mutations of E-cadherin gene in Korean familial gastric cancer patients." in: Journal of human genetics, Vol. 44, Issue 3, pp. 177-80, 1999 (PubMed).