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  • 产品名称：BoneMorphogeneticProteinReceptor1A(BMPR1A)(AA24-152)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
BoneMorphogeneticProteinReceptor1A(BMPR1A)(AA24-152)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.7 kDa. The protein migrates as 26 kDa and 32 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >97 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: Measured by its ability to inhibit rhBMP4 induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 for this effect is typically 0.02-0.15 μg/mL in the presence of 30 ng/mL of recombinant human BMP4.

SDS-PAGE: of reduced rhALK3.
Background The bone morphogenetic protein receptor, type IA is also known as BMPR1A or ALK3 is a protein which in humans is encoded by the BMPR1A gene. BMPR1A has also been designated as CD292 (cluster of differentiation 290). The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A (this protein) and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. Alk3-mediated BMP signaling in AV endocardial/mesenchymal cells plays a central role during cushion morphogenesis.
Molecular Weight 15.7 kDa
UniProt P36894
Pathways Stem Cell Maintenance
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
Supplier Images
SDS-PAGE (SDS) image for Bone Morphogenetic Protein Receptor 1A (BMPR1A) (AA 24-152) (Active) protein (His tag) (ABIN2180581) Human BMPR-IA, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ...
Background publications Mishina, Starbuck, Gentile, Fukuda, Kasparcova, Seedor, Hanks, Amling, Pinero, Harada, Behringer: "Bone morphogenetic protein type IA receptor signaling regulates postnatal osteoblast function and bone remodeling." in: The Journal of biological chemistry, Vol. 279, Issue 26, pp. 27560-6, 2004 (PubMed).