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  • 产品名称：WAPFour-DisulfideCoreDomain2(WFDC2)(AA31-124)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
WAPFour-DisulfideCoreDomain2(WFDC2)(AA31-124)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 10.9 kDa. The protein migrates as 19 kDa and 22-26 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Human Epididymis Protein 4 (HE4) is also known as WAP four-disulfide core domain protein 2 (WFDC2), Epididymal secretory protein E4, Major epididymis-specific protein E4, Putative protease inhibitor WAP5, is a member of the WFDC domain family. HE4 / WFDC2 is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. HE4 is also a small secretory protein, which may be involved in sperm maturation.
Molecular Weight 10.9 kDa
UniProt Q14508
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for WAP Four-Disulfide Core Domain 2 (WFDC2) (AA 31-124) (Active) protein (His tag) (ABIN2181198) Human HE4, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained over...
Background publications Hellström, Raycraft, Hayden-Ledbetter, Ledbetter, Schummer, McIntosh, Drescher, Urban, Hellström: "The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma." in: Cancer research, Vol. 63, Issue 13, pp. 3695-700, 2003 (PubMed).