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  • 产品名称：FrizzledFamilyReceptor5(AA27-167)(Active)protein(FcTag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
FrizzledFamilyReceptor5(AA27-167)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 42.6 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Frizzled-5 (FZD5) is also known as FzE5, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD5 contains one FZ (frizzled) domain. FZD5 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. FZD5 interacts specifically with Wnt5A to induce the beta-catenin pathway. FZD5 interacts with GOPC.
Molecular Weight 42.6 kDa
UniProt Q13467
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Frizzled Family Receptor 5 (AA 27-167) (Active) protein (Fc Tag) (ABIN2181128) Frizzled Family Receptor 5 (AA 27-167) (Active) protein (Fc Tag)
Background publications Hao, Xie, Zhang, Charlat, Oster, Avello, Lei, Mickanin, Liu, Ruffner, Mao, Ma, Zamponi, Bouwmeester, Finan, Kirschner, Porter, Serluca, Cong: "ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner." in: Nature, Vol. 485, Issue 7397, pp. 195-200, 2012 (PubMed).

Zhang, Liu, Li, Hao, Deng, Cheng, Liu, Xie: "[Involvement of dendritic cells frequency and function in outcomes of interferon-alpha therapy for chronic hepatitis B patients]." in: Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology, Vol. 26, Issue 2, pp. 120-2, 2012 (PubMed).

Hsieh, Rattner, Smallwood, Nathans: "Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 7, pp. 3546-51, 1999 (PubMed).