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  • 产品名称：EphrinA4(EFNA4)(AA26-171)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
EphrinA4(EFNA4)(AA26-171)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 17.2 kDa. The protein migrates as 20-22 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Ephrin-A4 (EFNA4) is also known as EPH-related receptor tyrosine kinase ligand 4 (LERK4), EPLG4, which belongs to the ephrin family. EFNA4 contains one ephrin RBD (ephrin receptor-binding) domain. EFNA4 is cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. EFNA4 binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. EFNA4 may play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils.
Molecular Weight 17.2 kDa
UniProt P52798
Pathways RTK Signaling
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Ephrin A4 (EFNA4) (AA 26-171) (Active) protein (His tag) (ABIN2181028) Human Ephrin-A4, His Tag on SDS-PAGE under reducing (R) condition. The gel was staine...
Background publications Aasheim, Munthe, Funderud, Smeland, Beiske, Logtenberg: "A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes." in: Blood, Vol. 95, Issue 1, pp. 221-30, 2000 (PubMed).

Kozlosky, Maraskovsky, McGrew, VandenBos, Teepe, Lyman, Srinivasan, Fletcher, Gayle, Cerretti: "Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins." in: Oncogene, Vol. 10, Issue 2, pp. 299-306, 1995 (PubMed).