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  • 产品名称：Basigin(OkBloodGroup)(BSG)(AA22-205)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
Basigin(OkBloodGroup)(BSG)(AA22-205)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 21.6 kDa. The protein migrates as 26-33 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: Measured by the ability of the immobilized protein to induce active MMP1 secretion by NHLF human normal lung fibroblasts. The ED50 for this effect is typically 0.5-4 μg/mL.
Background CD147, also known as Basigin (BSG), or extracellular matrix metalloproteinase inducer (EMMPRIN). The human basigin protein contains 269 amino acids that form two heavily glycosylated C2 type immunoglobulin-like domains at the N-terminal extracellular portion. A second form of basigin has also been characterized that contains one additional immunoglobulin-like domain in its extracellular portion. As members of the immunoglobulin superfamily play fundamental roles in intercellular recognition involved in various immunologic phenomena, differentiation, and development, basigin is thought also to play a role in intercellular recognition and regulate several distinct functions, such as spermatogenesis, expression of the monocarboxylate transporter and the responsiveness of lymphocytes. Basigin is a type I integral membrane receptor that has many ligands, including the cyclophilin (CyP) proteins Cyp-A and CyP-B and certain integrins.
Molecular Weight 21.6 kDa
NCBI Accession NP_940991
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Basigin (Ok Blood Group) (BSG) (AA 22-205) (Active) protein (His tag) (ABIN2180694) Human EMMPRIN, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ...
Background publications Hakuma, Betsuyaku, Kinoshita, Itoh, Kaga, Kondo, Nishimura, Dosaka-Akita: "High incidence of extracellular matrix metalloproteinase inducer expression in non-small cell lung cancers. Association with clinicopathological parameters." in: Oncology, Vol. 72, Issue 3-4, pp. 197-204, 2008 (PubMed).

Kasinrerk, Fiebiger, Stefanová, Baumruker, Knapp, Stockinger: "Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse basigin, and chicken HT7 molecule." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 149, Issue 3, pp. 847-54, 1992 (PubMed).