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  • 产品名称：Interleukin1ReceptorAccessoryProtein(IL1RAP)(AA21-359)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
Interleukin1ReceptorAccessoryProtein(IL1RAP)(AA21-359)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 40 kDa. The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Interleukin-1 receptor accessory protein (IL1RAP or IL-1RAcP) is also known as Interleukin-1 receptor 3 (IL-1R-3 or IL-1R3), C3orf13, which belongs to the interleukin-1 receptor family. IL1RAP contains three Ig-like C2-type (immunoglobulin-like) domains and one TIR domain. IL1RAP is detected in liver, skin, placenta, thymus and lung. IL-1R3 / IL1RAP is coreceptor with IL1R1, associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways.
Molecular Weight 40 kDa
UniProt Q9NPH3
Pathways NF-kappaB Signaling, Growth Factor Binding
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Interleukin 1 Receptor Accessory Protein (IL1RAP) (AA 21-359) (Active) protein (His tag) (ABIN2749236) Human IL-1 RAcP, His Tag on SDS-PAGE under reducing (R) condition. The gel was staine...
Background publications Smith, Hanna, Della Friend, Moore, Chen, Farese, MacVittie, Virca, Sims: "The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action." in: Immunity, Vol. 18, Issue 1, pp. 87-96, 2003 (PubMed).

Worm, Jensen, Hansen, Søndergaard, Nybroe: "Interactions between proteolytic and non-proteolytic Pseudomonas fluorescens affect protein degradation in a model community." in: FEMS microbiology ecology, Vol. 32, Issue 2, pp. 103-109, 2000 (PubMed).

Jensen, Muzio, Mantovani, Whitehead: "IL-1 signaling cascade in liver cells and the involvement of a soluble form of the IL-1 receptor accessory protein." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 10, pp. 5277-86, 2000 (PubMed).

Huang, Gao, Li, Cao: "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 24, pp. 12829-32, 1998 (PubMed).