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  • 产品名称：Kininogen1(KNG1)(AA19-427)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
Kininogen1(KNG1)(AA19-427)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 46.6 kDa. The protein migrates as 50-68 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >92 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Kininogen-1 (KNG1) is also known as HMWK, BDK, KNG, is a secreted protein which contains three cystatin domains. KNG1 can be cleaved into the following six chains: Kininogen-1 heavy chain, T-kinin, Bradykinin, Lysyl-bradykinin, Kininogen-1 light chain, Low molecular weight growth-promoting factor. HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII, HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. LMW-kininogen inhibits the aggregation of thrombocytes, LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.
Molecular Weight 46.6 kDa
NCBI Accession NP_000884
UniProt P01042
Pathways ACE Inhibitor Pathway, Glycosaminoglycan Metabolic Process
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 100 mM Sodium Acetate, 100 mM NaCl, pH 5.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Kininogen 1 (KNG1) (AA 19-427) (Active) protein (His tag) (ABIN2181445) Human Kininogen 1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stai...
Background publications Wunderer, Walter, Eschenbacher, Lang, Kellermann, Kindermann: "Ile-Ser-bradykinin is an aberrant permeability factor in various human malignant effusions." in: Biological chemistry Hoppe-Seyler, Vol. 371, Issue 10, pp. 977-81, 1991 (PubMed).

Aron, Hertzeanu, Fisman, Frank, Kellermann: "Correlation between arrhythmias and abnormal systolic blood pressure response to exercise in mitral valve prolapse patients." in: Giornale italiano di cardiologia, Vol. 16, Issue 1, pp. 15-21, 1986 (PubMed).

Kellermann, Lottspeich, Henschen, Müller-Esterl: "Completion of the primary structure of human high-molecular-mass kininogen. The amino acid sequence of the entire heavy chain and evidence for its evolution by gene triplication." in: European journal of biochemistry / FEBS, Vol. 154, Issue 2, pp. 471-8, 1986 (PubMed).