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  • 产品名称：Interleukin29(IL29)(AA1-200)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
Interleukin29(IL29)(AA1-200)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 21.1 kDa. The protein migrates as 30-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Interleukin-29, is a secreted protein which belongs to the IL-28 / IL-29 family, and is a type III interferon. It is also known as cytokine Zcyto21, Interferon lambda-1, IFN-lambda-1, IFNλ1, IL-29 and IFNL1, and is highly similar in amino acid sequence to the IL-28, the other type III interferon. IL28A, IL28B, and IL29, also named interferonλ2 (IFNλ2), IFNλ3, and IFNλ1, respectively, are classII cytokine receptor ligands that are distantly related to members of the IL 10 family (11-13 % aa sequence identity) and the type I IFN family (15-19 % aa sequence identity). Human IL29 cDNA encodes a 200 amino acid (aa) residue precursor protein with a putative 19 aa signal peptide and a 181 aa mature protein, which is a monomer in solution. It shares 67 % and 69 % aa sequence identity with human IL28A and IL28B, respectively. IL-29 plays an important role in host defenses against microbes and its gene is highly upregulated in cells infected with viruses and also may play a role in antiviral immunity. Interleukin-29 / IL-29 up-regulates MHC class I antigen expression. It is a Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.
Molecular Weight 21.1 kDa
NCBI Accession NP_742152
UniProt Q8IU54
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
Supplier Images
SDS-PAGE (SDS) image for Interleukin 29 (IL29) (AA 1-200) (Active) protein (His tag) (ABIN2181309) Interleukin 29 (IL29) (AA 1-200) (Active) protein (His tag)
Background publications Vilcek: "Boosting p53 with interferon and viruses." in: Nature immunology, Vol. 4, Issue 9, pp. 825-6, 2003 (PubMed).

Sheppard, Kindsvogel, Xu, Henderson, Schlutsmeyer, Whitmore, Kuestner, Garrigues, Birks, Roraback, Ostrander, Dong, Shin, Presnell, Fox, Haldeman, Cooper, Taft, Gilbert, Grant, Tackett, Krivan et al.: "IL-28, IL-29 and their class II cytokine receptor IL-28R. ..." in: Nature immunology, Vol. 4, Issue 1, pp. 63-8, 2002 (PubMed).

Kotenko, Gallagher, Baurin, Lewis-Antes, Shen, Shah, Langer, Sheikh, Dickensheets, Donnelly: "IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex." in: Nature immunology, Vol. 4, Issue 1, pp. 69-77, 2002 (PubMed).