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  • 产品名称：CD2Molecule(CD2)(AA25-209)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
CD2Molecule(CD2)(AA25-209)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 22.7 kDa. The protein migrates as 33-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >98 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background T-cell surface antigen CD2 is also known as Erythrocyte receptor, LFA-2, LFA-3 receptor, Rosette receptor, T-cell surface antigen T11/Leu-5 and SRBC, is a single-pass type I membrane protein found on the surface of T cells and natural killer (NK) cells. CD2 is a member of the immunoglobulin superfamily. CD2 / SRBC contains 1 Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain. CD2 / SRBC interacts with other adhesion molecules, such as lymphocyte function-associated antigen-3 (LFA-3 / CD58) in humans, or CD48 in rodents, which are expressed on the surfaces of other cells. In addition to its adhesive properties, CD2 also acts as a co-stimulatory molecule on T and NK cells. CD2 is a specific marker for T cells and NK cells, and can therefore be used in immunohistochemistry to identify the presence of such cells in tissue sections.
Molecular Weight 22.7 kDa
UniProt P06729
Research Area Stem Cells, Hematopoietic Progenitors, Hematopoietic Stem Cells, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
Supplier Images
SDS-PAGE (SDS) image for CD2 Molecule (CD2) (AA 25-209) (Active) protein (His tag) (ABIN2180720) Human CD2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained over...
Background publications Wilkins, Yang, Yang: "Structural biology of the cell adhesion protein CD2: from molecular recognition to protein folding and design." in: Current protein & peptide science, Vol. 4, Issue 5, pp. 367-73, 2003 (PubMed).

Bodian, Jones, Harlos, Stuart, Davis: "Crystal structure of the extracellular region of the human cell adhesion molecule CD2 at 2.5 A resolution." in: Structure (London, England : 1993), Vol. 2, Issue 8, pp. 755-66, 1995 (PubMed).