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  • 产品名称：Dipeptidyl-Peptidase4(DPP4)(AA29-766)(Active)protein(FcTag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
Dipeptidyl-Peptidase4(DPP4)(AA29-766)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 112 kDa. The protein migrates as 90-120 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Dipeptidyl peptidase-IV (DPPIV) is also known as adenosine deaminase complexing protein 2, DPPIV or CD26 is antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation, signal transduction and apoptosis. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. The substrates of DPPIV are proline (or alanine)-containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides. DPPIV plays a major role in glucose metabolism. It is responsible for the degradation of incretins such as GLP-1. DPPIV plays an important role in tumor biology, and is useful as a marker for various cancers, with its levels either on the cell surface or in the serum increased in some neoplasms and decreased in others.[4] DPPIV also binds the enzyme adenosine deaminase specifically and with high affinity. The significance of this interaction has yet to be established.
Molecular Weight 112 kDa
NCBI Accession NP_001926
UniProt P27487
Pathways Peptide Hormone Metabolism, Regulation of Leukocyte Mediated Immunity
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
Supplier Images
SDS-PAGE (SDS) image for Dipeptidyl-Peptidase 4 (DPP4) (AA 29-766) (Active) protein (Fc Tag) (ABIN2180984) Dipeptidyl-Peptidase 4 (DPP4) (AA 29-766) (Active) protein (Fc Tag)
Background publications Havre, Abe, Urasaki, Ohnuma, Morimoto, Dang: "The role of CD26/dipeptidyl peptidase IV in cancer." in: Frontiers in bioscience : a journal and virtual library, Vol. 13, pp. 1634-45, 2007 (PubMed).

Chen: "Biochemical properties of recombinant prolyl dipeptidases DPP-IV and DPP8." in: Advances in experimental medicine and biology, Vol. 575, pp. 27-32, 2006 (PubMed).

Endo, Harigae, Nagai, Fujie, Meguro, Watanabe, Furuyama, Kameoka, Okuda, Hayashi: "Two chronic myelogenous leukaemia cell lines which represent different stages of erythroid differentiation." in: British journal of haematology, Vol. 85, Issue 4, pp. 653-62, 1994 (PubMed).

Morimoto, Lord, Zhang, Duke-Cohan, Letvin, Schlossman: "Role of CD26/dipeptidyl peptidase IV in human immunodeficiency virus type 1 infection and apoptosis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 21, pp. 9960-4, 1994 (PubMed).

Kameoka, Tanaka, Nojima, Schlossman, Morimoto: "Direct association of adenosine deaminase with a T cell activation antigen, CD26." in: Science (New York, N.Y.), Vol. 261, Issue 5120, pp. 466-9, 1993 (PubMed).