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  • 产品名称：CD79bMolecule,Immunoglobulin-Associatedbeta(CD79B)(AA29-159)(Active)protein(FcT

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  • 产品厂商：ACROBiosystems
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简单介绍：
CD79bMolecule,Immunoglobulin-Associatedbeta(CD79B)(AA29-159)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 41.8 kDa. The protein migrates as 50-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >92 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background B-cell antigen receptor complex-associated protein beta chain (CD79b) is also known as B-cell-specific glycoprotein B29, Ig-beta,Immunoglobulin-associated B29 protein, B29 and IGB, which is a single-pass type I membrane protein containing one Ig-like V-type ( immunoglobulin-like ) domain and one ITAM domain.CD79b is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR).CD79b can enhance phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79b are the cause of agammaglobulinemia type 6 (AGM6) that is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development.
Molecular Weight 41.8 kDa
NCBI Accession NP_000617
UniProt P40259
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for CD79b Molecule, Immunoglobulin-Associated beta (CD79B) (AA 29-159) (Active) protein (Fc Tag) (ABIN2180837) Human CD79B, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained ove...
Background publications Radaev, Zou, Huang, Lafer, Hinck, Sun: "Ternary complex of transforming growth factor-beta1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily." in: The Journal of biological chemistry, Vol. 285, Issue 19, pp. 14806-14, 2010 (PubMed).

Radaev, Zou, Tolar, Nguyen, Nguyen, Krueger, Stutzman, Pierce, Sun: "Structural and functional studies of Igalphabeta and its assembly with the B cell antigen receptor." in: Structure (London, England : 1993), Vol. 18, Issue 8, pp. 934-43, 2010 (PubMed).

Lee, Luisiri, Clark: "A novel complex, p40/42, is constitutively associated with the B cell antigen receptor and phosphorylated upon receptor stimulation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 157, Issue 9, pp. 3828-37, 1996 (PubMed).

Luisiri, Lee, Eisfelder, Clark: "Cooperativity and segregation of function within the Ig-alpha/beta heterodimer of the B cell antigen receptor complex." in: The Journal of biological chemistry, Vol. 271, Issue 9, pp. 5158-63, 1996 (PubMed).

Vasile, Coligan, Yoshida, Seon: "Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex." in: Molecular immunology, Vol. 31, Issue 6, pp. 419-27, 1994 (PubMed).