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  • 产品名称：beta-2-Microglobulin(B2M)(AA21-119)(Active)protein(StrepTag,Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
beta-2-Microglobulin(B2M)(AA21-119)(Active)protein(StrepTag,Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 12.5 kDa. The protein migrates as 15 kDa under reducing (R) condition (SDS-PAGE).
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background β2 microglobulin is also known as Beta-2-microglobulin (B2M), is a component of MHC class I molecules which belongs to the beta-2-microglobulin family. B2M is present on all nucleated cells (excludes red blood cells). B2M associates not only with the alpha chain of MHC class I molecules, but also with class I-like molecules such as CD1 and Qa. An additional function of B2M is association with the HFE protein, together regulating the expression of hepcidin in the liver which targets the iron transporter ferroportin on the cytoplasmic membrane of enterocytes and macrophages for degradation resulting in decreased iron uptake from food and iron release from recycled red blood cells respectively. Loss of this function causes iron excess and hemochromatosis. Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP).
Molecular Weight 12.5 kDa
NCBI Accession NP_036644
UniProt P07151
Pathways TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for beta-2-Microglobulin (B2M) (AA 21-119) (Active) protein (Strep Tag,His tag) (ABIN2180615) Rat beta 2-Microglobulin, His Tag on SDS-PAGE under reducing (R) condition. The gel w...
Background publications Momoi, Suzuki, Titani, Hisanaga, Ogawa, Saito: "Amino acid sequence of a modified beta 2-microglobulin in renal failure patient urine and long-term dialysis patient blood." in: Clinica chimica acta; international journal of clinical chemistry, Vol. 236, Issue 2, pp. 135-44, 1995 (PubMed).

Bhattacharyya, Chavan, Haley, Taylor, Collins: "Identification of the NADP(H) of rat liver microsomal 5 alpha-reductase (isozyme-1): purification of a photolabeled peptide corresponding to the adenine binding domain." in: Biochemistry, Vol. 34, Issue 11, pp. 3663-9, 1995 (PubMed).

Collins, Garboczi, Karpusas, Wiley: "The three-dimensional structure of a class I major histocompatibility complex molecule missing the alpha 3 domain of the heavy chain." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 4, pp. 1218-21, 1995 (PubMed).

Argilés, Derancourt, Jauregui-Adell, Mion, Demaille: "Biochemical characterization of serum and urinary beta 2 microglobulin in end-stage renal disease patients." in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Vol. 7, Issue 11, pp. 1106-10, 1993 (PubMed).

Gorevic, Munoz, Casey, DiRaimondo, Stone, Prelli, Rodrigues, Poulik, Frangione: "Polymerization of intact beta 2-microglobulin in tissue causes amyloidosis in patients on chronic hemodialysis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, Issue 20, pp. 7908-12, 1986 (PubMed).