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  • 产品名称：CD177Molecule(CD177)(AA22-407)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
CD177Molecule(CD177)(AA22-407)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 42 kDa. The protein migrates as 53 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background CD antigen CD177 is also known as Polycythemia rubra vera protein 1 (PRV-1), Human neutrophil alloantigen 2a, NB1 glycoprotein, is a glycosyl-phosphatidylinositol (GPI)-linked N-glycosylated cell surface glycoprotein. CD177 contains two UPAR/Ly6 domains. CD177 is highly expressed in normal bone marrow and weakly expressed in fetal liver. PECAM-1 is a binding partner of CD177.
Molecular Weight 42 kDa
UniProt Q8N6Q3
Research Area CD Antigens, Surface Receptors of Immune Cells
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for CD177 Molecule (CD177) (AA 22-407) (Active) protein (His tag) (ABIN2180708) Human CD177, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ov...
Background publications Zhang, Henzel: "Signal peptide prediction based on analysis of experimentally verified cleavage sites." in: Protein science : a publication of the Protein Society, Vol. 13, Issue 10, pp. 2819-24, 2004 (PubMed).

Klippel, Strunck, Busse, Behringer, Pahl: "Biochemical characterization of PRV-1, a novel hematopoietic cell surface receptor, which is overexpressed in polycythemia rubra vera." in: Blood, Vol. 100, Issue 7, pp. 2441-8, 2002 (PubMed).

Temerinac, Klippel, Strunck, Röder, Lübbert, Lange, Azemar, Meinhardt, Schaefer, Pahl: "Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera." in: Blood, Vol. 95, Issue 8, pp. 2569-76, 2000 (PubMed).