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  • 产品名称：MacrophageScavengerReceptor1(MSR1)(AA77-451)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
MacrophageScavengerReceptor1(MSR1)(AA77-451)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 42.1 kDa. The protein migrates as 65-72 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized rhMSR1 at 5 μg/mL (100 μL/well) can bind biotinylated advanced glycation endproducts of bovine serum albumin (AGE-BSA) with a linear range of 1 - 150 ng/mL.
Background Macrophage scavenger receptor 1 (MSR1) is also known as CD204, SCARA1, SR-A, and is class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. Defects in MSR1 may be a cause of prostate cancer (PC) or Barrett esophagus (BE).
Molecular Weight 42.1 kDa
NCBI Accession NP_619729
UniProt P21757
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
Supplier Images
SDS-PAGE (SDS) image for Macrophage Scavenger Receptor 1 (MSR1) (AA 77-451) (Active) protein (His tag) (ABIN2181520) Human MSR1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ove...
Background publications Orloff, Peterson, He, Ganapathi, Heald, Yang, Bebek, Romigh, Song, Wu, David, Cheng, Meltzer, Eng: "Germline mutations in MSR1, ASCC1, and CTHRC1 in patients with Barrett esophagus and esophageal adenocarcinoma." in: JAMA, Vol. 306, Issue 4, pp. 410-9, 2011 (PubMed).

Xu, Zheng, Komiya, Mychaleckyj, Isaacs, Hu, Sterling, Lange, Hawkins, Turner, Ewing, Faith, Johnson, Suzuki, Bujnovszky, Wiley, DeMarzo, Bova, Chang, Hall, McCullough, Partin, Kassabian, Carpten et al.: "Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk. ..." in: Nature genetics, Vol. 32, Issue 2, pp. 321-5, 2002 (PubMed).

Gough, Greaves, Gordon: "A naturally occurring isoform of the human macrophage scavenger receptor (SR-A) gene generated by alternative splicing blocks modified LDL uptake." in: Journal of lipid research, Vol. 39, Issue 3, pp. 531-43, 1998 (PubMed).