产品详情
  • 产品名称:ProteintyrosinePhosphataseTypeIVA,Member2(PTP4A2)(AA2-164)(Active)protein(GSTta

  • 产品型号:
  • 产品厂商:ACROBiosystems
  • 产品文档:
你添加了1件商品 查看购物车
简单介绍:
ProteintyrosinePhosphataseTypeIVA,Member2(PTP4A2)(AA2-164)(Active)protein(GSTtag)
详情介绍:
Characteristics This protein carries a GST tag at the N-terminus. The protein has a calculated MW of 45.9 kDa. The protein migrates as 46 kDa under reducing (R) condition (SDS-PAGE).
Purity >92 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Protein tyrosine phosphatase type IVA 2 (PTP4A2),a member of the protein-tyrosine phosphatase family, is also known as Protein-tyrosine phosphatase 4a2, Protein-tyrosine phosphatase of regenerating liver 2 (PRL-2), PRL2 and PTPCAAX2,which is ubiquitously expressed, with highest levels in skeletal muscle, heart and thymus and over expressed in prostate tumor tissue. PTP4A2 contains one tyrosine-protein phosphatase domain. In contrast to PTP4A1 and PTP4A3, PTP4A2 does not interact with tubulin but RABGGTB.PTP4A2 stimulates progression from G1 into S phase during mitosis and promotes tumors. PTP4A2 can also inhibit geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.The acticity of PTP4A2 is inhibited by sodium orthovanadate and pentamidine.
Molecular Weight 45.9 kDa
UniProt Q12974
Research Area Cancer, Cell Cycle, Kinases/Phosphatases
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM HEPES, 150 mM NaCl, pH 7.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Protein tyrosine Phosphatase Type IVA, Member 2 (PTP4A2) (AA 2-164) (Active) protein (GST tag) (ABIN2181677) Human PTP4A2, GST Tag on SDS-PAGE under reducing (R) condition. The gel was stained o...
Background publications Pathak, Dhawan, Lindner, Borden, Farver, Yi: "Pentamidine is an inhibitor of PRL phosphatases with anticancer activity." in: Molecular cancer therapeutics, Vol. 1, Issue 14, pp. 1255-64, 2003 (PubMed).

Gjörloff-Wingren, Saxena, Han, Wang, Alonso, Renedo, Oh, Williams, Schnitzer, Mustelin: "Subcellular localization of intracellular protein tyrosine phosphatases in T cells." in: European journal of immunology, Vol. 30, Issue 8, pp. 2412-21, 2000 (PubMed).

Cates, Michael, Stayrook, Harvey, Burke, Randall, Crowell, Crowell: "Prenylation of oncogenic human PTP(CAAX) protein tyrosine phosphatases." in: Cancer letters, Vol. 110, Issue 1-2, pp. 49-55, 1997 (PubMed).