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  • 产品名称：Transthyretin(TTR)(AA21-147)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
Transthyretin(TTR)(AA21-147)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 14.6 kDa. The protein migrates as 19 kDa and 37 kDa under reducing (R) condition (SDS-PAGE) due to the monomer and dimer respectively.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: Measured by its ability to bind biotinylated human RBP4 in a functional ELISA.
Background Transthyretin (TTR) is also known as Prealbumin, ATTR, TBPA, PALB, which belongs to the transthyretin family. Transthyretin / TTR is a serum and cerebrospinal fluid carrier of the thyroid hormone thyroxine (T4) and retinol-binding protein bound to retinol. In cerebrospinal fluid TTR is the primary carrier of T4. TTR also acts as a carrier of retinol (vitamin A) through its association with retinol-binding protein (RBP) in the blood and the CSF. Less than 1 % of TTR's T4 s are occupied in blood. TTR misfolding and aggregation is known to be associated with the amyloid diseases.
Molecular Weight 14.6 kDa
NCBI Accession NP_000362
UniProt P02766
Pathways Hormone Transport
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Transthyretin (TTR) (AA 21-147) (Active) protein (His tag) (ABIN2181876) Human Transthyretin, His Tag on SDS-PAGE under reducing (R) condition. The gel was st...
Background publications Getz, Kennedy, Mangini: "Transthyretin localization in cultured and native human retinal pigment epithelium." in: Experimental eye research, Vol. 68, Issue 5, pp. 629-36, 1999 (PubMed).

Herbert, Moore, de la Riva, Watts: "Endocrine responses and examination anxiety." in: Biological psychology, Vol. 22, Issue 3, pp. 215-26, 1986 (PubMed).

Herbert, Wilcox, Pham, Fremeau, Zeviani, Dwork, Soprano, Makover, Goodman, Zimmerman: "Transthyretin: a choroid plexus-specific transport protein in human brain. The 1986 S. Weir Mitchell award." in: Neurology, Vol. 36, Issue 7, pp. 900-11, 1986 (PubMed).

Nakaki, Mita, Yamamoto, Nakadate, Kato: "Inhibition by palmitoylcarnitine of adhesion and morphological changes in HL-60 cells induced by 12-O-tetradecanoylphorbol-13-acetate." in: Cancer research, Vol. 44, Issue 5, pp. 1908-12, 1984 (PubMed).

Mita, Maeda, Shimada, Araki: "Cloning and sequence analysis of cDNA for human prealbumin." in: Biochemical and biophysical research communications, Vol. 124, Issue 2, pp. 558-64, 1984 (PubMed).