产品详情
查看大图

  • 产品名称：AmyloidPComponent,serum(APCS)(AA20-223)(Active)protein(Histag)

  • 产品型号：
  • 产品厂商：ACROBiosystems
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
AmyloidPComponent,serum(APCS)(AA20-223)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 24 kDa. The protein migrates as 26 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Serum amyloid P-component (SAP) is also known as Pentraxin 2 (PTX2), APCS, which belongs to the pentaxin family. SAP contains one pentaxin domain. PTX2 is a secreted homopentamer protein which is found in serum and urine. SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits. SAP can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. SAP may also function as a calcium-dependent lectin. SAP has certain sequence homology with C-reactive protein (CRP).
Molecular Weight 24 kDa
NCBI Accession NP_001630
UniProt P02743
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 150 mM NaCl, pH 7.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Amyloid P Component, serum (APCS) (AA 20-223) (Active) protein (His tag) (ABIN2180596) Amyloid P Component, serum (APCS) (AA 20-223) (Active) protein (His tag)
Background publications Kiernan, Nedelkov, Tubbs, Niederkofler, Nelson: "Proteomic characterization of novel serum amyloid P component variants from human plasma and urine." in: Proteomics, Vol. 4, Issue 6, pp. 1825-9, 2004 (PubMed).

Pepys, Rademacher, Amatayakul-Chantler, Williams, Noble, Hutchinson, Hawkins, Nelson, Gallimore, Herbert: "Human serum amyloid P component is an invariant constituent of amyloid deposits and has a uniquely homogeneous glycostructure." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 12, pp. 5602-6, 1994 (PubMed).

Frangione, Moloshok, Prelli, Solomon: "Human lambda light-chain constant region gene CMor lambda: the primary structure of lambda VI Bence Jones protein Mor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 82, Issue 10, pp. 3415-9, 1985 (PubMed).

Prelli, Pras, Frangione: "The primary structure of human tissue amyloid P component from a patient with primary idiopathic amyloidosis." in: The Journal of biological chemistry, Vol. 260, Issue 24, pp. 12895-8, 1985 (PubMed).