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  • 产品名称：Angiopoietin-Like4(ANGPTL4)(AA166-406)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
Angiopoietin-Like4(ANGPTL4)(AA166-406)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 27.9 kDa. The protein migrates as 33-36 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Angiopoietin-related protein 4 (ANGPTL4) is also known as Hepatic fibrinogen / angiopoietin - related protein (HFARP), ARP4, PGAR. ANGPTL4 contains one fibrinogen C-terminal domain. ANGPTL4 is a homooligomer , and the homooligomer undergoes proteolytic processing to release its carboxyl fibrinogen-like domain, which circulates as a monomer. The homooligomer unprocessed form is able to interact with the extracellular matrix. ANGPTL4 may act as a regulator of angiogenesis and modulate tumorigenesis. ANGPTL4 inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 may exert a protective function on endothelial cells through an endocrine action.
Molecular Weight 27.9 kDa
NCBI Accession NP_647475
UniProt Q9BY76
Pathways Regulation of Lipid Metabolism by PPARalpha
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM MOPS, 100 mM NaCl, pH 7.2 with 0.1 % CHAPS
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Angiopoietin-Like 4 (ANGPTL4) (AA 166-406) (Active) protein (His tag) (ABIN2180590) Angiopoietin-Like 4 (ANGPTL4) (AA 166-406) (Active) protein (His tag)
Background publications Ito, Oike, Yasunaga, Hamada, Miyata, Matsumoto, Sugano, Tanihara, Masuho, Suda: "Inhibition of angiogenesis and vascular leakiness by angiopoietin-related protein 4." in: Cancer research, Vol. 63, Issue 20, pp. 6651-7, 2003 (PubMed).

Zhu, Li, Wan, Yang, Qin, Ge, Yao, Gu: "[Expression and function of hepatocellular carcinoma-related gene pp1158]." in: Zhonghua zhong liu za zhi [Chinese journal of oncology], Vol. 24, Issue 2, pp. 123-5, 2002 (PubMed).

Nam, Yoon, Park: "A novel fabrication method of macroporous biodegradable polymer scaffolds using gas foaming salt as a porogen additive." in: Journal of biomedical materials research, Vol. 53, Issue 1, pp. 1-7, 2000 (PubMed).

Yoon, Chickering, Rosen, Dussault, Qin, Soukas, Friedman, Holmes, Spiegelman: "Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation." in: Molecular and cellular biology, Vol. 20, Issue 14, pp. 5343-9, 2000 (PubMed).