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  • 产品名称：ReceptorTyrosineKinase-LikeOrphanReceptor2(ROR2)(AA34-403)(Active)protein(FcTag

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  • 产品厂商：ACROBiosystems
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简单介绍：
ReceptorTyrosineKinase-LikeOrphanReceptor2(ROR2)(AA34-403)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 68 kDa. The protein migrates as 80-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Tyrosine-protein kinase transmembrane receptor ROR2 is also known as Neurotrophic tyrosine kinase, receptor-related 2 (NTRKR2), which belongs to the protein kinase superfamily and Tyr protein kinase family and ROR subfamily. ROR2 is a homodimer protein, which can binds YWHAB or interact with WTIP. ROR2 may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development.
Molecular Weight 68 kDa
NCBI Accession NP_004551
UniProt Q01974
Research Area Stem Cells, Extracellular Matrix, Tyrosine Kinases
Pathways RTK Signaling, WNT Signaling
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2) (AA 34-403) (Active) protein (Fc Tag) (ABIN2181706) Human ROR2, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained over...
Background publications Liu, Ross, Bodine, Billiard: "Homodimerization of Ror2 tyrosine kinase receptor induces 14-3-3(beta) phosphorylation and promotes osteoblast differentiation and bone formation." in: Molecular endocrinology (Baltimore, Md.), Vol. 21, Issue 12, pp. 3050-61, 2007 (PubMed).

Afzal, Rajab, Fenske, Oldridge, Elanko, Ternes-Pereira, Tüysüz, Murday, Patton, Wilkie, Jeffery: "Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2." in: Nature genetics, Vol. 25, Issue 4, pp. 419-22, 2000 (PubMed).

van Bokhoven, Celli, Kayserili, van Beusekom, Balci, Brussel, Skovby, Kerr, Percin, Akarsu, Brunner: "Mutation of the gene encoding the ROR2 tyrosine kinase causes autosomal recessive Robinow syndrome." in: Nature genetics, Vol. 25, Issue 4, pp. 423-6, 2000 (PubMed).