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  • 产品名称：CD9(CD9)(AA112-195)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
CD9(CD9)(AA112-195)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 10.7 kDa. The protein migrates as 11 kDa under reducing (R) condition (SDS-PAGE).
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background CD9 antigen is also known as tetraspanin-29 (TSPAN29), 5H9 antigen, Leukocyte antigen MIC3 (MIC3), Motility-related protein, is a multi-pass membrane protein which belongs to the tetraspanin (TM4SF) family or the transmembrane 4 superfamily. CD9 is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. TSPAN29 is found on the surface of exosomes. MIC3 Involved in platelet activation and aggregation, regulates paranodal junction formation and also Involved in cell adhesion, cell motility and tumor metastasis. CD9 antigen also seems to be a key part in the egg-sperm fusion during mammalian fertilization.
Molecular Weight 10.7 kDa
NCBI Accession NP_001760
UniProt P21926
Research Area Embryogenesis, Embryonic stem cells, Reproduction, CD Antigens, Surface Receptors of Immune Cells
Pathways Response to Water Deprivation, Cell-Cell Junction Organization
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
Supplier Images
SDS-PAGE (SDS) image for CD9 (CD9) (AA 112-195) (Active) protein (His tag) (ABIN2180855) Human CD9, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained over...
Background publications Muranova, Ruzheinikov, Higginbottom, Clipson, Blackburn, Wentworth, Datta, Rice, Partridge: "Crystallization of a carbamatase catalytic antibody Fab fragment and its complex with a transition-state analogue." in: Acta crystallographica. Section D, Biological crystallography, Vol. 60, Issue Pt 1, pp. 172-4, 2003 (PubMed).

Higginbottom, Takahashi, Bolling, Coonrod, White, Partridge, Monk: "Structural requirements for the inhibitory action of the CD9 large extracellular domain in sperm/oocyte binding and fusion." in: Biochemical and biophysical research communications, Vol. 311, Issue 1, pp. 208-14, 2003 (PubMed).

Masellis-Smith, Shaw: "CD9-regulated adhesion. Anti-CD9 monoclonal antibody induce pre-B cell adhesion to bone marrow fibroblasts through de novo recognition of fibronectin." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 152, Issue 6, pp. 2768-77, 1994 (PubMed).

Ikeyama, Koyama, Yamaoko, Sasada, Miyake: "Suppression of cell motility and metastasis by transfection with human motility-related protein (MRP-1/CD9) DNA." in: The Journal of experimental medicine, Vol. 177, Issue 5, pp. 1231-7, 1993 (PubMed).