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  • 产品名称：CathepsinS(CTSS)(AA109-331)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
CathepsinS(CTSS)(AA109-331)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 36.6 kDa. The protein migrates as 37 kDa (pro) and 26 kDa (mature) under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2. The specific activity is >300 pmol/min/μg.
Background Cathepsin S is also known as CTSS, which is a member of the peptidase C1 family. Cathepsin S is a lysosomal cysteine protease that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. Cathepsin S can function as an elastase over a broad pH range in alveolar macrophages. The catalytic activity of cathepsin S is similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.
Molecular Weight 36.6 kDa
NCBI Accession NP_004070
UniProt P25774
Research Area Proteolysis / Ubiquitin, Organelles, Adaptive Immunity, Proteases
Pathways Activation of Innate immune Response, Toll-Like Receptors Cascades
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM MES, 100 mM NaCl, pH 6.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Cathepsin S (CTSS) (AA 109-331) (Active) protein (His tag) (ABIN2180950) Human Cathepsin S, His Tag on SDS-PAGE under reducing (R) condition. The gel was stai...
Background publications Burkard, Planyavsky, Kaupe, Breitwieser, Bürckstümmer, Bennett, Superti-Furga, Colinge: "Initial characterization of the human central proteome." in: BMC systems biology, Vol. 5, pp. 17, 2011 (PubMed).