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  • 产品名称：GlycoproteinA33(Transmembrane)(GPA33)(AA22-235)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
GlycoproteinA33(Transmembrane)(GPA33)(AA22-235)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 24.7 kDa. The protein migrates as 35-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Glycoprotein A33 (GPA33) is also known as Cell surface A33 antigen, is a single-pass type I membrane protein which is expressed in normal gastrointestinal epithelium and in 95 % of colon cancers. GPA33 The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 1 Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily, which contains. GPA33 may play a role in cell-cell recognition and signaling.
Molecular Weight 24.7 kDa
NCBI Accession NP_067623
UniProt Q99795
Research Area Cancer
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Glycoprotein A33 (Transmembrane) (GPA33) (AA 22-235) (Active) protein (His tag) (ABIN2181181) Mouse GPA33, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ov...
Background publications Heath, White, Johnstone, Catimel, Simpson, Moritz, Tu, Ji, Whitehead, Groenen, Scott, Ritter, Cohen, Welt, Old, Nice, Burgess: "The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 2, pp. 469-74, 1997 (PubMed).