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  • 产品名称：anti-CD46Molecule,ComplementRegulatoryProtein(CD46)antibody(FITC)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-CD46Molecule,ComplementRegulatoryProtein(CD46)antibody(FITC)
详情介绍：
Immunogen Human pancreatic carcinoma cell line (AsPC1)
Clone TGP3
Isotype IgG2a
Purification Protein A agarose
Alternative Name CD46 / MCP (CD46 Antibody Abstract)
Background CD46, also known as membrane cofactor protein (MCP), was first described as a membrane complement regulator that fu nctions as a cofactor with factor I to cleave complement factors C3b and C4b and thereby protect the cell from co mplement attack. In humans, CD46 is expressed on all nuc leated cells. In the rodent animals, its expression is limited only in testis, indicating that the major function of CD46 among different species lies in fertilization. CD46 and other membrane complement regulatory proteins (CD55 and CD59) are frequently overexpressed on cancer cells, possibly as a mechanism for cancer cells to overcome lysis by complement. Several pathogens, including viruses and bacteria (measles virus, human herpesvirus 6, human group B and D adenoviruses, Streptococcus pyogenes , and pathogenic Neisseria species) have been reported to use CD46 for invasion. Recent evidence also indicates that CD 46 signaling events play an important role in linking innate and acquired immune function.Synonyms: MIC10, Membrane cofactor protein, TLX, Trophoblast leukocyte common antigen
Gene ID 9606
UniProt P15529
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways Regulation of Actin Filament Polymerization
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 1 % BSA and 0.09 % NaN3
Storage 4 °C
Storage Comment Store at 2-8 °C.
Supplier Images
Flow Cytometry (FACS) image for anti-CD46 Molecule, Complement Regulatory Protein (CD46) antibody (FITC) (ABIN1449264) anti-CD46 Molecule, Complement Regulatory Protein (CD46) antibody (FITC)
Background publications Johansson, Rytkonen, Bergman, Albiger, Källström, Hökfelt, Agerberth, Cattaneo, Jonsson: "CD46 in meningococcal disease." in: Science (New York, N.Y.), Vol. 301, Issue 5631, pp. 373-5, 2003 (PubMed).

Marie, Astier, Rivailler, Rabourdin-Combe, Wild, Horvat: "Linking innate and acquired immunity: divergent role of CD46 cytoplasmic domains in T cell induced inflammation." in: Nature immunology, Vol. 3, Issue 7, pp. 659-66, 2002 (PubMed).