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  • 产品名称：anti-E-cadherinantibody(Cadherin1,Type1,E-Cadherin(Epithelial))(PE)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-E-cadherinantibody(Cadherin1,Type1,E-Cadherin(Epithelial))(PE)
详情介绍：
Immunogen T-47D cells
Clone 67A4
Isotype IgG1
Specificity This antibody 67A4 recognizes CD324 / E-cadherin, an approximately 100 kDa epithelial cell adhesion molecule, whose detection is important for determination of invasive potential of epithelial neoplasms.
Cross-Reactivity (Details) Species reactivity (tested):Human
Alternative Name CD324 / Cadherin-1 (CDH1 Antibody Abstract)
Background CD324 / E-cadherin is an epithelial cell surface molecule, which provides calcium-dependent homophilic interactions with E-cadherin of another cell. These intaractions take part in morphogenetic programs controlling the maintenance of the structural and functional integrity of epithelia and affect invasive potential of epithelial neoplasms. CD324 / E-cadherin is implicated in cell growth and differentiation, cell recognition, and sorting during developmental morphogenesis, as well as in aggregation-dependent cell survival. CD324 / E-cadherin-mediated cell adhesion system is highly regulated from inside the cell by a number of intracellular signaling pathways.Synonyms: CAM 120/80, CDH1, CDHE, E-cadherin, Epithelial cadherin, UVO, Uvomorulin
Gene ID 999, 9606
UniProt P12830
Research Area Extracellular Matrix, Signaling, Cytoskeleton
Pathways Sensory Perception of Sound, Cell-Cell Junction Organization, Tube Formation
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2 % (w/v) high-grade protease free Bovine Serum Albumin (BSA)
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice DO NOT FREEZE! This product is photosensitive and should be protected from light.
Storage 4 °C
Product cited in: Lin, Liao, Lee, Hung, Sayion, Chen, Kang, Huang, Cherng: "Molecular events associated with epithelial to mesenchymal transition of nasopharyngeal carcinoma cells in the absence of Epstein-Barr virus genome." in: Journal of biomedical science, Vol. 16, pp. 105, 2009 (PubMed).

Furio, Guezennec, Ducarre, Guesnet, Peguet-Navarro: "Differential effects of allergens and irritants on early differentiating monocyte-derived dendritic cells." in: European journal of dermatology : EJD, Vol. 18, Issue 2, pp. 141-7, 2008 (PubMed).

Caberg, Hubert, Begon, Herfs, Roncarati, Boniver, Delvenne: "Silencing of E7 oncogene restores functional E-cadherin expression in human papillomavirus 16-transformed keratinocytes." in: Carcinogenesis, Vol. 29, Issue 7, pp. 1441-7, 2008 (PubMed).

Background publications Robertson, Ali, McDonnell, Burt, Kirby: "Chronic renal allograft dysfunction: the role of T cell-mediated tubular epithelial to mesenchymal cell transition." in: Journal of the American Society of Nephrology : JASN, Vol. 15, Issue 2, pp. 390-7, 2004 (PubMed).

Novak, Kraft, Haberstok, Geiger, Allam, Bieber: "A reducing microenvironment leads to the generation of FcepsilonRIhigh inflammatory dendritic epidermal cells (IDEC)." in: The Journal of investigative dermatology, Vol. 119, Issue 4, pp. 842-9, 2002 (PubMed).

Kutlesa, Wessels, Speiser, Steiert, Müller, Klein: "E-cadherin-mediated interactions of thymic epithelial cells with CD103+ thymocytes lead to enhanced thymocyte cell proliferation." in: Journal of cell science, Vol. 115, Issue Pt 23, pp. 4505-15, 2002 (PubMed).

Pece, Gutkind: "Signaling from E-cadherins to the MAPK pathway by the recruitment and activation of epidermal growth factor receptors upon cell-cell contact formation." in: The Journal of biological chemistry, Vol. 275, Issue 52, pp. 41227-33, 2001 (PubMed).

Servet-Delprat, Vidalain, Bausinger, Manié, Le Deist, Azocar, Hanau, Fischer, Rabourdin-Combe: "Measles virus induces abnormal differentiation of CD40 ligand-activated human dendritic cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 4, pp. 1753-60, 2000 (PubMed).

Pece, Chiariello, Murga, Gutkind et al.: "Activation of the protein kinase Akt/PKB by the formation of E-cadherin-mediated cell-cell junctions. Evidence for the association of phosphatidylinositol 3-kinase with the E-cadherin adhesion ..." in: The Journal of biological chemistry, Vol. 274, Issue 27, pp. 19347-51, 1999 (PubMed).

Bühring, Müller, Herbst, Cole, Rappold, Schuller, Zhu, Fritzsch, Faul, Armeanu, Ullrich, Klein, Schmidt: "The adhesion molecule E-cadherin and a surface antigen recognized by the antibody 9C4 are selectively expressed on erythroid cells of defined maturational stages." in: Leukemia, Vol. 10, Issue 1, pp. 106-16, 1996 (PubMed).

Armeanu, Bühring, Reuss-Borst, Müller, Klein: "E-cadherin is functionally involved in the maturation of the erythroid lineage." in: The Journal of cell biology, Vol. 131, Issue 1, pp. 243-9, 1995 (PubMed).

Takeichi: "Cadherin cell adhesion receptors as a morphogenetic regulator." in: Science (New York, N.Y.), Vol. 251, Issue 5000, pp. 1451-5, 1991 (PubMed).