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  • 产品名称：anti-FLT3antibody(Fms-RelatedtyrosineKinase3)(PE)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-FLT3antibody(Fms-RelatedtyrosineKinase3)(PE)
详情介绍：
Immunogen BV-173 leukemic cell line
Clone BV10A4
Isotype IgG1
Specificity This antibody reacts with CD135 (FLT3, FLK2, STK-1), a 130-160 kDa type III receptor tyrosine kinase that is involved in early steps of hematopoiesis.
Cross-Reactivity (Details) Species reactivity (tested):Human, negative in mouse
Alternative Name CD135 / FLT3 (FLT3 Antibody Abstract)
Background CD135 / FLT3, also known as FLK2 or STK-1 is a receptor tyrosine kinase that plays important roles in hematopoiesis. After binding of Flt3 ligand (FL), CD135 homodimerizes and stimulates proliferation, differentiation and protects the cell from apoptosis. The loss of CD90 and gain of CD135 expression marks the loss of self-renewal in hematopoietic stem cell population. Detectable CD135 expression appears first at low levels on the surface of primitive multilineage progenitor cells and disappears during defined stages of B-cell development, but is upregulated and maintained during maturation of monocytes. CD135 is also expressed on thymocytes, dendritic cell progenitors and on mature dendritic cells, as well as on various malignant hematopoietic cells.Synonyms: FL cytokine receptor, STK1, Stem cell tyrosine kinase 1, Tyrosine-protein kinase receptor FLT3
Gene ID 2322
NCBI Accession NP_004110
UniProt P36888
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways RTK Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2 % (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice DO NOT FREEZE! This product is photosensitive and should be protected from light.
Storage 4 °C
Background publications Whartenby, Calabresi, McCadden, Nguyen, Kardian, Wang, Mosse, Pardoll, Small: "Inhibition of FLT3 signaling targets DCs to ameliorate autoimmune disease." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 46, pp. 16741-6, 2005 (PubMed).

Kuchenbauer, Kern, Schoch, Kohlmann, Hiddemann, Haferlach, Schnittger: "Detailed analysis of FLT3 expression levels in acute myeloid leukemia." in: Haematologica, Vol. 90, Issue 12, pp. 1617-25, 2005 (PubMed).

Christensen, Weissman: "Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 25, pp. 14541-6, 2001 (PubMed).

Rappold, Ziegler, Köhler, Marchetto, Rosnet, Birnbaum, Simmons, Zannettino, Hill, Neu, Knapp, Alitalo, Alitalo, Ullrich, Kanz, Bühring: "Functional and phenotypic characterization of cord blood and bone marrow subsets expressing FLT3 (CD135) receptor tyrosine kinase." in: Blood, Vol. 90, Issue 1, pp. 111-25, 1997 (PubMed).

Haylock, Horsfall, Dowse, Ramshaw, Niutta, Protopsaltis, Peng, Burrell, Rappold, Buhring, Simmons: "Increased recruitment of hematopoietic progenitor cells underlies the ex vivo expansion potential of FLT3 ligand." in: Blood, Vol. 90, Issue 6, pp. 2260-72, 1997 (PubMed).