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  • 产品名称：anti-CD36antibody(CD36Molecule(thrombospondinReceptor))(PE)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-CD36antibody(CD36Molecule(thrombospondinReceptor))(PE)
详情介绍：
Immunogen Platelets.
Clone TR9
Isotype IgG1
Characteristics Synonyms: Glycoprotein IIIb, PAS IV, PAS-4, Thrombospondin receptor, GP3B, GP4, Plateletglycoprotein 4, Platelet glycoprotein IV, Platelet collagen receptor, Fatty acid translocase
Purification Size-Exclusion Chromatography.
Alternative Name CD36 (CD36 Antibody Abstract)
Background CD36 (fatty acid translocase, FAT) is an 88 kDa ditopic glycosylated protein that belongs to the class B family of scavenger receptors. CD36 is expressed by most resting marginal zone B cells but not by follicular and B1 B cells, and it is rapidly induced on Follicular B cells in vitro upon TLR and CD40 stimulation. CD36 does not affect the development of B cells, but modulates both primary and secondary antibody response. Similarly to glucose transporter GLUT4, CD36 is translocated from intracellular pools to the plasma membrane following cell stimulation by insulin. In mouse, CD36 is responsible for gustatory perception of long-chain fatty acids.Synonyms: Fatty acid translocase, GP3B, GP4, Glycoprotein IIIb, PAS IV, PAS-4, Platelet collagen receptor, Platelet glycoprotein 4, Platelet glycoprotein IV, Thrombospondin receptor
UniProt P16671
Research Area Cancer, Atherosclerosis, Hematopoietic Progenitors, Hematopoietic Stem Cells, CD Antigens, Surface Receptors of Immune Cells
Pathways TLR Signaling, Peptide Hormone Metabolism, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades
Application Notes Suitable for Flow Cytometry analysis of human blood cells using 20 μL reagent / 100 μL ofwhole blood or 10^6 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 15 mM sodium azide as preservative and 0.2 % (w/v) high-grade BSA (Protease free) as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody in the dark at 2-8 °C. DO NOT FREEZE! Avoid prolonged exposure to light.
Shelf life: One year from despatch.
Expiry Date 12 months
Supplier Images
Flow Cytometry (FACS) image for anti-CD36 antibody (CD36 Molecule (thrombospondin Receptor)) (PE) (ABIN238511) anti-CD36 Molecule (thrombospondin Receptor) (CD36) antibody (PE)
Background publications Gaillard, Laugerette, Darcel, El-Yassimi, Passilly-Degrace, Hichami, Khan, Montmayeur, Besnard: "The gustatory pathway is involved in CD36-mediated orosensory perception of long-chain fatty acids in the mouse." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 22, Issue 5, pp. 1458-68, 2008 (PubMed).

van Oort, van Doorn, Bonen, Glatz, van der Horst, Rodenburg, Luiken: "Insulin-induced translocation of CD36 to the plasma membrane is reversible and shows similarity to that of GLUT4." in: Biochimica et biophysica acta, Vol. 1781, Issue 1-2, pp. 61-71, 2008 (PubMed).

Won, Bachmann, Kearney: "CD36 is differentially expressed on B cell subsets during development and in responses to antigen." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 1, pp. 230-7, 2007 (PubMed).