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  • 产品名称：anti-ITGALantibody(Integrinalpha-L)(FITC)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-ITGALantibody(Integrinalpha-L)(FITC)
详情介绍：
Immunogen Splenic PHA blasts. Spleen cells from immunised BALB/c mice were fused with cells from the PAI mouse myeloma cell line.
Clone WT-1
Isotype IgG2a
Specificity This antibody reacts with CD11a, a glycoprotein of 160-170 kDa which is associated with CD18. Functionally, this monoclonal inhibits homotypic aggregation of PHA blasts. It also blocks binding of rat lymphocytes to purified rat ICAM-1.
Purification Affinity chromatography on Protein A
Alternative Name CD11a / ITGAL (ITGAL Antibody Abstract)
Background CD11a is one of the leucocyte integrins (b2 integrin) which plays an important role in leucocyte physiology.Synonyms: CD11 antigen-like family member A, Integrin alpha-L, LFA-1, LFA1, Leukocyte adhesion glycoprotein LFA-1 alpha chain, Leukocyte function-associated molecule 1 alpha chain
Gene ID 308995
NCBI Accession NP_001029170
UniProt Q3T1L6
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways Activated T Cell Proliferation, Integrin Complex
Application Notes Flow Cytometry: Neat - 1/10, Use 10 μL of the suggested working dilution to label 10^6 cells in 100 μL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, pH 7.2 containing 0.09 % Sodium Azide and 1 % Bovine Serum Albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing. Should it contain a precipitate we recommend microcentrifugation before use.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Tamatani, Kotani, Miyasaka: "Characterization of the rat leukocyte integrin, CD11/CD18, by the use of LFA-1 subunit-specific monoclonal antibodies." in: European journal of immunology, Vol. 21, Issue 3, pp. 627-33, 1991 (PubMed).

Tamatani, Kotani, Tanaka, Miyasaka: "Molecular mechanisms underlying lymphocyte recirculation. II. Differential regulation of LFA-1 in the interaction between lymphocytes and high endothelial cells." in: European journal of immunology, Vol. 21, Issue 3, pp. 855-8, 1991 (PubMed).