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  • 产品名称：anti-S100A9antibody(S100CalciumBindingProteinA9)(Biotin)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-S100A9antibody(S100CalciumBindingProteinA9)(Biotin)
详情介绍：
Immunogen Purified granulocyte antigen of Human origin.
Clone CF-557
Isotype IgG1
Specificity This antibody Binds to Human Calgranulin B (S100A9). Other species not tested.
Purification Protein G Chromatography of Ascitic fluid.
Alternative Name S100A9 / Calgranulin-B / MRP14 (S100A9 Antibody Abstract)
Background Calgranulin B, also known as MRP-14 and S100A9 is a member of the S100 family of proteins containing 2 EF hand (alpha helix, turn, alpha helix structure) calcium binding motifs. S100 proteins are localized in the cytoplasm and /or nucleus of a wide range of cells and are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. MRP-14 (S100A9) forms a heterodimeric complex with MRP-8 (S100A8) in the cytosol of monocyte and neutrophil cell types circulating in peripheral blood. Calgranulin B is found in elevated levels in the serum of cystic fibrosis cases and is also expressed in the skin of patients with psoriasis, eczematous dermatitis and squamous cell carcinoma. Calgranulin B is also expressed on macrophages in acute inflamed tissues (peridontitis, contact excema).Synonyms: CAGB, Calprotectin L1H subunit, Leukocyte L1 complex heavy chain, MRP-14, Migration inhibitory factor-related protein 14, S100 calcium-binding protein A9, S100-A9
Gene ID 6280
NCBI Accession NP_002956
UniProt P06702
Pathways Transition Metal Ion Homeostasis, Positive Regulation of Endopeptidase Activity
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS containing 0.02 % Sodium Azide as preservative and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Thacher, Nagpal, Klein, Arefieg, Krasinski, DiSepio, Agarwal, Johnson, Eckert, Chandraratna: "Cell type and gene-specific activity of the retinoid inverse agonist AGN 193109: divergent effects from agonist at retinoic acid receptor gamma in human keratinocytes." in: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 10, Issue 4, pp. 255-62, 1999 (PubMed).

Nagpal, Thacher, Patel, Friant, Malhotra, Shafer, Krasinski, Asano, Teng, Duvic, Chandraratna: "Negative regulation of two hyperproliferative keratinocyte differentiation markers by a retinoic acid receptor-specific retinoid: insight into the mechanism of retinoid action in psoriasis." in: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 7, Issue 12, pp. 1783-91, 1997 (PubMed).

Klein, Pino, Johnson, Davies, Nagpal, Thacher, Krasinski, Chandraratna: "Identification and functional separation of retinoic acid receptor neutral antagonists and inverse agonists." in: The Journal of biological chemistry, Vol. 271, Issue 37, pp. 22692-6, 1996 (PubMed).