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  • 产品名称：anti-CD11bantibody(IntegrinalphaM)(FITC)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-CD11bantibody(IntegrinalphaM)(FITC)
详情介绍：
Clone VIM12
Isotype IgG1
Specificity This antibody clone VIM12 (clone renamed, formerly Bear-1) reacts with the CD11b alpha chain of the CD11b/CD18 (p165, 95) integrin heterodimer complex present on Human NK cells, monocytes, and granulocytes. The recognized structure is the alpha chain of a heterodimer glycoprotein of Mw 165 kDa (alpha chain) and 95 kDa (beta chain).
Cross-Reactivity (Details) Species reactivity (tested):Human.
Characteristics Absorption / Emission: 488 nm / 525 nm
Alternative Name CD11b (ITGAM Antibody Abstract)
Background CD11b is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement coated particles. It is identical to CR3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the RGD peptide in C3b. CD11b is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. The Mac1 CD11b antigen is present on macrophages, granulocytes, natural killer cells, blood monocytes. CD11b is expressed on 8 % spleen cells, 44 % bone marrow cells and less than 1 % of thymocytes and is commonly used as a microglial marker in nervous tissue.Synonyms: CD11 antigen-like family member B, CR-3 alpha chain, CR3A, Cell surface glycoprotein MAC-1 subunit alpha, ITGAM, Integrin alpha-M, Leukocyte adhesion receptor MO1, MAC1, Neutrophil adherence receptor
Gene ID 3684
NCBI Accession NP_000623
UniProt P11215
Research Area Stem Cells, Hematopoietic Progenitors, Hematopoietic Stem Cells, Glia marker, CD Antigens, Surface Receptors of Immune Cells
Pathways Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Buffer 0.09 % Sodium Azide Highly purified grade of BSA has been added as a stabilizing protein to bring the final protein concentration to 4-5 mg/mL.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice DO NOT FREEZE! This product is photosensitive and should protected from light.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Background publications Thornton, Vĕtvicka, Pitman, Goldman, Ross: "Analysis of the sugar specificity and molecular location of the beta-glucan-binding lectin site of complement receptor type 3 (CD11b/CD18)." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 156, Issue 3, pp. 1235-46, 1996 (PubMed).

Bohuslav, Horejsí, Hansmann, Stöckl, Weidle, Majdic, Bartke, Knapp, Stockinger: "Urokinase plasminogen activator receptor, beta 2-integrins, and Src-kinases within a single receptor complex of human monocytes." in: The Journal of experimental medicine, Vol. 181, Issue 4, pp. 1381-90, 1995 (PubMed).

Stöckl, Majdic, Pickl, Rosenkranz, Prager, Gschwantler, Knapp: "Granulocyte activation via a near the C-terminal region of complement receptor type 3 alpha-chain (CD11b) potentially involved in intramembrane complex formation with glycosylphosphatidylinositol-anchored Fc gamma RIIIB (CD16) molecules." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 10, pp. 5452-63, 1995 (PubMed).