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  • 产品名称：anti-CLEC7Aantibody(C-TypeLectinDomainFamily7,MemberA)(FITC)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-CLEC7Aantibody(C-TypeLectinDomainFamily7,MemberA)(FITC)
详情介绍：
Immunogen Dectin-1 transfected NIH3T3 cells and recombinant soluble Dectin-1.
Clone 2A11
Isotype IgG2b
Specificity Recognises Murine beta-Glucan Receptor (Dectin-1). Dectin-1 is predominantly expressed by cells of the monocyte/macrophage and neutrophil lineages, but also at lower levels by dendritic cells and a subpopulation of T cells. This antibody inhibits the binding of zymosan to macrophages via the beta-glucan receptor. The low endotoxin version SM2025LE is recommended for Functional Studies.
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Alternative Name CLEC7A / Dectin-1 (CLEC7A Antibody Abstract)
Background As a major leucocyte receptor for beta-glucan this molecule may have a key role in the immunomodulatory effects of beta-glucans and in the host response to fungal pathogens. Recent work has shown that Dectin-1 may stimulate reactive oxygen production in macropahges via the protein tyrosine kinase known as Syk.Synonyms: BGR, Beta-glucan receptor, C-type lectin domain family 7 member A, C-type lectin superfamily member 12, CLECSF12, DC-associated C-type lectin 1, DECTIN1, Dendritic cell-associated C-type lectin 1
Gene ID 56644
NCBI Accession NP_064392
UniProt Q6QLQ4
Pathways Activation of Innate immune Response
Application Notes Flow Cytometry (/10-1/50): Use 10 μL of the suggested working dilution to label 10^6 cells in 100 μL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Underhill, Rossnagle, Lowell, Simmons: "Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production." in: Blood, Vol. 106, Issue 7, pp. 2543-50, 2005 (PubMed).

Reid, Montoya, Taylor, Borrow, Gordon, Brown, Wong: "Expression of the beta-glucan receptor, Dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactions." in: Journal of leukocyte biology, Vol. 76, Issue 1, pp. 86-94, 2004 (PubMed).

Brown, Taylor, Reid, Willment, Williams, Martinez-Pomares, Wong, Gordon: "Dectin-1 is a major beta-glucan receptor on macrophages." in: The Journal of experimental medicine, Vol. 196, Issue 3, pp. 407-12, 2002 (PubMed).

Taylor, Brown, Reid, Willment, Martinez-Pomares, Gordon, Wong: "The beta-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 7, pp. 3876-82, 2002 (PubMed).