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  • 产品名称：anti-CSF3Rantibody(ColonyStimulatingFactor3Receptor(Granulocyte))(PE)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-CSF3Rantibody(ColonyStimulatingFactor3Receptor(Granulocyte))(PE)
详情介绍：
Clone LMM775
Isotype IgG1
Specificity This antibody recognises the G-CSF receptor, expressed by peripheral blood granulocytes and some myeloid cell lines.
Purification Affinity Chromatography on Protein A.
Alternative Name CD114 / CSF3R (CSF3R Antibody Abstract)
Background The protein encoded by the GCSF Receptor gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Four transcript variants encoding four different isoforms have been found for this gene, of which three are membrane-bound and the one secreted and soluble. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia.Synonyms: G-CSF Receptor, G-CSF-R, GCSF Receptor, GCSFR, Granulocyte colony-stimulating factor receptor
Gene ID 1441
NCBI Accession NP_000751
UniProt Q99062
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore with 0.25 mL distilled water.
Concentration 1.0 mg/mL
Buffer PBS containing 0.09 % Sodium Azide as preservative and 1 % BSA and 5 % sucrose as stabilizers.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice This product is photosensitive and should be protected from light
Storage 4 °C
Storage Comment Prior to and following reconstitution store the antibody at 2-8 °C. DO NOT FREEZE!
Background publications Nicholson, Oates, Harpur, Ziemiecki, Wilks, Layton: "Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 8, pp. 2985-8, 1994 (PubMed).