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  • 产品名称：anti-L-Selectinantibody(SelectinL)(PE)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-L-Selectinantibody(SelectinL)(PE)
详情介绍：
Immunogen PHA stimulated lymphoblasts. Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line.
Clone FMC46
Isotype IgG2b
Specificity This antibody recognizes CD62L, also known a L-selectin.
Purification Affinity chromatography on Protein G
Alternative Name CD62L / L-Selectin (SELL Antibody Abstract)
Target Type Chemical
Background CD62L is a 74-95? kDa member of the selectin family of adhesion receptors, which acts as a ligand for both CD62-P (P-selectin) and CD62E (E-selectin). Human CD62L is constitutively expressed on most leucocytes including monocytes, granulocytes, lymphocytes, NK cells, bone marrow myeloid progenitor cells and on a subset of thymocytes. CD62L plays an important role in leucocyte tethering and rolling on the endothelial cell surface and for the homing of naive lymphocytes to lymph nodes and Peyers patches via HEV. Neutrophils require a constant supply of this molecule on the cell surface for migration into peripheral tissues and adhesion to activated endothelium at sites of inflammation, where CD62L is rapidly shed as soluble L-selectin, but surface expression still remains. The expression of CD62L is down regulated on lymphocytes and neutrophils by PMA stimulation.Synonyms: CD62 antigen-like family member L, LAM-1, LECAM1, LNHR, LYAM1, Leu-8, Leukocyte adhesion molecule 1, Leukocyte surface antigen Leu-8, Leukocyte-endothelial cell adhesion molecule 1, Lymph node homing receptor, SELL, TQ1, gp90-MEL
Gene ID 6402
NCBI Accession NP_000646
UniProt P14151
Application Notes Flow Cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore with 0.25 mL distilled water.
Buffer PBS, pH 7.2 containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice This product is photosensitive and should be protected from light
Storage 4 °C
Storage Comment Prior to and following reconstitution store the antibody at 2-8 °C. DO NOT FREEZE!
Background publications Yoshino, Ami, Terao, Tashiro, Honda: "Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies." in: Experimental animals / Japanese Association for Laboratory Animal Science, Vol. 49, Issue 2, pp. 97-110, 2000 (PubMed).

Sopp, Howard: "Cross-reactivity of monoclonal antibodies to defined human leucocyte differentiation antigens with bovine cells." in: Veterinary immunology and immunopathology, Vol. 56, Issue 1-2, pp. 11-25, 1997 (PubMed).

Zola, Macardle, Flego, Webster: "The expression of sub-population markers on B cells: a re-evaluation using high-sensitivity fluorescence flow cytometry." in: Disease markers, Vol. 9, Issue 2, pp. 103-18, 1992 (PubMed).

Pilarski, Turley, Shaw, Gallatin, Laderoute, Gillitzer, Beckman, Zola: "FMC46, a cell protrusion-associated leukocyte adhesion molecule-1 epitope on human lymphocytes and thymocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 147, Issue 1, pp. 136-43, 1991 (PubMed).