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  • 产品名称：anti-SLC3A2antibody(SoluteCarrierFamily3(ActivatorsofDibasicandNeutralAminoAcid

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-SLC3A2antibody(SoluteCarrierFamily3(ActivatorsofDibasicandNeutralAminoAcidTransport),Member2)(FITC)
详情介绍：
Immunogen HOON pre-B leukaemia cell line. Spleen cells from immunised BALB/c mice were fused with cells of the SP2 Ag14 mouse myeloma cell line.
Clone 44D7
Isotype IgG1
Specificity This antibody reacts with the heavy chain of the CD98 Molecule. The epitope is distinct from clone 44H7 (Cat#SM1173), but the same as recognised by 4F2. This antibody binds to all cell lines in culture and to activated Tcells.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity Chromatography on Protein G.
Alternative Name CD98 / SLC3A2 (SLC3A2 Antibody Abstract)
Background CD98 is a type II transmembrane glycoprotein which associates with members of the L type amino transporter family to form a heterodimeric complex CD98 constitutes the heavy chain of the complex and is required for the surface expression and basolateral localization of the amino acid transporter complex in polarized epithelial cells. The CD98 heavy chain also interacts with beta 1 integrins and regulates their activation through the cytoplasmic domains and transmembrane regions. Studies suggest that overexpression of CD98 may contribute to cell growth and survival by regulating integrin signalling, and therefore may play an important role in tumorigenesis. The tissue distribution of this antigen is broad. Monocytes express high levels of CD98 antigen. Peripheral blood T and B cells, as well as NK cells and granulocytes express low levels of CD98 antigen. Activation of T cells and NK cells leads to upregulation of this antigen.Synonyms: 4F2 cell-surface antigen heavy chain, 4F2 heavy chain antigen, 4F2hc, Lymphocyte activation antigen 4F2 large subunit, MDU1
Gene ID 6520
NCBI Accession NP_001012680
UniProt P08195
Application Notes Flow cytometry: Use 10 μL of neat-1/10 diluted antibody to label 10^6 cells in 100 μL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Letarte, Quackenbush, Baumal, Michalak: "Correlations between the 44D7 antigenic complex and the plasma membrane Na+-Ca2+ exchanger." in: Biochemistry and cell biology = Biochimie et biologie cellulaire, Vol. 64, Issue 11, pp. 1160-9, 1987 (PubMed).