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  • 产品名称：anti-CD22antibody(CD22Molecule)(Biotin)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-CD22antibody(CD22Molecule)(Biotin)
详情介绍：
Immunogen CD22 isolated from Daudi cells. Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line.
Clone Mc64-12
Isotype IgG1
Cross-Reactivity (Details) Species reactivity (tested):Human, Bovine, Sheep.
Purification Affinity Chromatography on Protein A
Alternative Name CD22 (CD22 Antibody Abstract)
Background CD22 is a type 1 integral membrane glycoprotein with molecular weight of 130 to 140kD. It is expressed in both the cytoplasm and cell membrane of B lymphocytes. CD22 antigen appears early in B cell lymphocyte differentiation at approximately the same stage as the CD19 antigen. Unlike other B cell markers, CD22 membrane expression is limited to the late differentiation stages comprised between mature B cells (CD22+) and plasma cells (CD22-), and may thus prove useful in phenotyping mature leukemias. CD22 is also strongly expressed in hairy cell leukemia. There are two different isoforms of CD22. It exists predominantly as a monomer of the beta isoform but can also be found as a heterodimer composed of the beta isoform and a second, shorter isoform (CD22 alpha).Synonyms: B-cell receptor CD22, B-lymphocyte cell adhesion molecule, BL-CAM, Leu-14, SIGLEC2, Sialic acid-binding Ig-like lectin 2, Siglec-2
Gene ID 9606
UniProt P20273
Research Area Stem Cells, Hematopoietic Progenitors, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, pH 7.4, 0.09 % Sodium azide, 1 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Griebel, Entrican, Rocchi, Beskorwayne, Davis: "Cross-reactivity of mAbs to human CD antigens with sheep leukocytes." in: Veterinary immunology and immunopathology, Vol. 119, Issue 1-2, pp. 115-22, 2007 (PubMed).

Sopp, Werling, Baldwin: "Cross-reactivity of mAbs to human CD antigens with cells from cattle." in: Veterinary immunology and immunopathology, Vol. 119, Issue 1-2, pp. 106-14, 2007 (PubMed).