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  • 产品名称：anti-SLPIantibody(SecretoryLeukocytePeptidaseInhibitor)(Biotin)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-SLPIantibody(SecretoryLeukocytePeptidaseInhibitor)(Biotin)
详情介绍：
Immunogen SLPI purified from sputum
Clone 31
Isotype IgG1
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Protein G
Alternative Name Antileukoproteinase (ALP) (SLPI Antibody Abstract)
Background SLPI was identified as an alarm reactant and expression is induced by inflammatory factors like LPS, IL1β, TNFα and neutrophils elastase. SLPI is a relatively small basic antiprotease of 11.7 kDa and is a cationic non-glycosylated protein consisting of 107amino acids. SLPI has a high affinity for the neutrophil serine proteinases, elastase and cathepsin G. Orthologues of SLPI have been found in mice, rate, pigs and sheep. It consists of two highly similar WAP ('whey acid protein')/four-disulphide core domains. SLPI contain 16 cysteine residues which assemble into eight disulphide bridges (four in each WAP domain). SLPI is constitutively expressed at many mucosal surfaces and is produced by a variety of epithelial cells, including respiratory, intestinal and amniotic epithelia. Expression is also detected in mast cells, neutrophils and macrophages. Expression of SLPI gene is significantly increased by progesterone and by the pro-inflammatory cytokines TNF-α and IL1-β. Although SLPI has been shown to inhibit a spectrum of proteases (including HNE, cathepsin G, trypsin, chymotrypsin and chymase), its main action in this regard is likely to be the inhibition of elastase, as indicated by its low dissociation constant and favourable kinetics of inhibition for this enzyme. SLPI has been described in several body fluids like seminal fluid, bronchial fluids, cervical fluids and saliva. It has been found to be antibacterial, antifungal, anti-retroviral, and to have an important role in mucosal defence. SLPI might also facilitate tumor spread, contributing to wound healing, is elevated in sepsis and levels seem to correlate with oral candidiasis in HIV-1 positive patients.Synonyms: BLPI, HUSI-1, Mucus proteinase inhibitor, Protease inhibitor WAP4, SLPI, Secretory leukocyte protease inhibitor, Seminal proteinase inhibitor, WAP four-disulfide core domain protein 4, WAP4, WFDC4
UniProt P03973
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 2 - 8 °C.
Supplier Images
Western Blotting (WB) image for anti-SLPI antibody (Secretory Leukocyte Peptidase Inhibitor) (Biotin) (ABIN1105385) anti-Secretory Leukocyte Peptidase Inhibitor (SLPI) antibody (Biotin)
Background publications Subramaniyam, Hollander, Westin, Erjefält, Stevens, Janciauskiene: "Secretory leukocyte protease inhibitor inhibits neutrophil apoptosis." in: Respirology (Carlton, Vic.), Vol. 16, Issue 2, pp. 300-7, 2011 (PubMed).

Cheng, Wang, Huang, Liang, Lin, Hsueh, Wu, Chen, Yu, Lin, Lin: "Overexpression of a secretory leukocyte protease inhibitor in human gastric cancer." in: International journal of cancer. Journal international du cancer, Vol. 123, Issue 8, pp. 1787-96, 2008 (PubMed).

Bingle, Cross, High, Wallace, Rassl, Yuan, Hellstrom, Campos, Bingle: "WFDC2 (HE4): a potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocarcinomas of the lung." in: Respiratory research, Vol. 7, pp. 61, 2006 (PubMed).

Aarbiou, van Schadewijk, Stolk, Sont, de Boer, Rabe, van Krieken, Mauad, Hiemstra: "Human neutrophil defensins and secretory leukocyte proteinase inhibitor in squamous metaplastic epithelium of bronchial airways." in: Inflammation research : official journal of the European Histamine Research Society ... [et al.], Vol. 53, Issue 6, pp. 230-8, 2004 (PubMed).

Nakao, Hanada, Asano, Hara, Abdus Salam, Matin, Shimazu, Nakasone, Horibata, Aoba, Honda, Amagasa, Senpuku: "Assessment of oral transmission using cell-free human immunodeficiency virus-1 in mice reconstituted with human peripheral blood leucocyte." in: Immunology, Vol. 109, Issue 2, pp. 271-82, 2003 (PubMed).

Wingens, van Bergen, Hiemstra, Meis, van Vlijmen-Willems, Zeeuwen, Mulder, Kramps, van Ruissen, Schalkwijk: "Induction of SLPI (ALP/HUSI-I) in epidermal keratinocytes." in: The Journal of investigative dermatology, Vol. 111, Issue 6, pp. 996-1002, 1999 (PubMed).