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  • 产品名称：anti-CD7antibody(CD7)(FITC)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-CD7antibody(CD7)(FITC)
详情介绍：
Clone B-B7
Isotype IgG1
Specificity Clone B-B7 recognizes a 40 kDa T cell and NK cell antigen.
Purification Affinity chromatography
Alternative Name CD7 (CD7 Antibody Abstract)
Background CD7 is the earliest antigen marker expressed in the T lineage, being found on T cell precursors in fetal liver and thorax prior to thymic colonization and in thymus and bone marrow. The function of CD7 antigen is unknown and the natural ligand for CD7 has not yet been identified. CD7 monoclonal antibodies co-stimulate T cell proliferation and induce second messengers, while soluble recombinant CD7 has been reported to inhibit antigen-specific proliferation and a mixed lymphocyte reaction. CD7 is a marker for pluripotential stem cell leukemias and T cell acute lymphocytic leukemia (T-ALL). The antigen is frequently lost on large cell T cell lymphomas. The CD7 antigen may also be expressed on myeloblastic leukemias.Synonyms: GP40, Leu-9, T-cell leukemia antigen, TP41
Gene ID 924
NCBI Accession NP_006128
UniProt P09564
Research Area Immunology, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Pathways Cell-Cell Junction Organization
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer 0.01 M sodium phosphate, 0.15 M NaCl, pH 7.3, 0.2 % BSA, 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C. This product is photosensitive and should be protected from light.
Supplier Images
image for anti-CD7 antibody (CD7) (FITC) (ABIN1106542) anti-CD7 (CD7) antibody (FITC)
Background publications Tang, Kim, Holmes, Hügin, Kenny, Chattopadhyay, Hartley, Morse: "Contribution of B cell subsets to delayed development of MAIDS in xid mice." in: Cellular immunology, Vol. 165, Issue 1, pp. 1-6, 1995 (PubMed).

Schanberg, Lee, Fleenor, Ware, Patel, Haynes, Kaufman: "Characterization of human CD7 transgenic mice." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 155, Issue 5, pp. 2407-18, 1995 (PubMed).

Ward, Parry, LeFeuvre, Sansom, Westwick, Lazarovits: "Antibody ligation of CD7 leads to association with phosphoinositide 3-kinase and phosphatidylinositol 3,4,5-trisphosphate formation in T lymphocytes." in: European journal of immunology, Vol. 25, Issue 2, pp. 502-7, 1995 (PubMed).

Haynes, Denning, Singer, Kurtzberg: "Ontogeny of T-cell precursors: a model for the initial stages of human T-cell development." in: Immunology today, Vol. 10, Issue 3, pp. 87-91, 1989 (PubMed).