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  • 产品名称：anti-CD22antibody(CD22Molecule)(FITC)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-CD22antibody(CD22Molecule)(FITC)
详情介绍：
Clone B-ly8
Isotype IgG1
Specificity Clone B-ly8 produces mouse IgG1 immunoglobulins directed against CD22, molecular weight 130-140 kDa.
Purification Affinity chromatography
Alternative Name CD22 (CD22 Antibody Abstract)
Background CD22 is detected in the cytoplasm early in B cell development (late pro-B cell stage), appears on the cell surface simultaneously with surface IgD, and is found on most mature B cells. Expression is lost with terminal differentiation of B cells and is absent on plasma cells. Activation of B cells via surface Ig increases CD22 expression [1]. It is more strongly expressed on prolymphocytic leukemia and HCL than in chronic lymphocytic leukemia. B cell lineage ALL express membrane and cytoplasmic CD22. CD22 forms a loose complex with the BcR cell antigen receptor (BcR) [2]. The cytoplasmic domain is tyrosine phosphorylated upon ligation of the BCR and associates via SH2 domains with the tyrosine phosphatase SHP-1, the tyrosine kinase Syk and phospholipase C-g1 [3,4]. CD22 down-modulates the B cell activation threshold, presumably through its association with SHP-1 and other signaling molecules [2,3]. Mice deficient in CD22 show exaggerated antibody responses to antigen and have raised levels of autoantibodies [1,5]. CD22 can also mediate cell adhesion through its interaction with cell surface molecules bearing the appropriate sialoglycoconjugates, but only when these conjugates are not on the CD22 bearing cell itself [2,6].Synonyms: B-cell receptor CD22, B-lymphocyte cell adhesion molecule, BL-CAM, Leu-14, SIGLEC2, Sialic acid-binding Ig-like lectin 2, Siglec-2
Gene ID 933
NCBI Accession NP_001172028
UniProt P20273
Research Area Stem Cells, Hematopoietic Progenitors, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer 0.01 M sodium phosphate, 0.15 M NaCl, pH 7.3, 0.2 % BSA, 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C. Fluorochrome labelled product is photosensitive and should be protected from light.
Supplier Images
image for anti-CD22 antibody (CD22 Molecule) (FITC) (ABIN1106081) anti-CD22 Molecule (CD22) antibody (FITC)
Background publications Hoffmann, Reichhart, Hetru: "Innate immunity in higher insects." in: Current opinion in immunology, Vol. 8, Issue 1, pp. 8-13, 1996 (PubMed).

Young, Inaba: "Dendritic cells as adjuvants for class I major histocompatibility complex-restricted antitumor immunity." in: The Journal of experimental medicine, Vol. 183, Issue 1, pp. 7-11, 1996 (PubMed).

Schwartz-Albiez, Dörken, Monner, Moldenhauer: "CD22 antigen: biosynthesis, glycosylation and surface expression of a B lymphocyte protein involved in B cell activation and adhesion." in: International immunology, Vol. 3, Issue 7, pp. 623-33, 1991 (PubMed).