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  • 产品名称：anti-ComplementComponent(3d/EpsteinBarrVirus)Receptor2(CR2)antibody(FITC)

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简单介绍：
anti-ComplementComponent(3d/EpsteinBarrVirus)Receptor2(CR2)antibody(FITC)
详情介绍：
Clone B-ly4
Isotype IgG1
Specificity Clone B-ly4 produces mouse IgG1 immunoglobulins directed against a 145 kDa polypeptide of the C3d receptor. Clone B-ly4 was clustered at the Leucocyte Typing Workshop IV [5].
Purification Affinity chromatography
Alternative Name CD21 (CR2 Antibody Abstract)
Background The CD21 antigen is expressed on mature B cells, follicular dendritic cells and pharyngeal and cervical epithelial cells [1,2]. CD21, also known as the Complement receptor type 2 (CR2) or Epstein-Barr virus (EBV) receptor, is a receptor for the C3 activation fragments iC3b and C3d. CD21 is part of a multimeric complex on B cells which includes CD19 and CD81 [3]. The ligand for CD21 is generated during activation of complement by the attachment of C3d to potential antigen. This creates fusion proteins that may cross-link the CD19-CD21-CD81 complex to sIg on antigen-specific B cells. The resulting signal transduction lowers the threshold for cellular activation. This enables an antibody reaction to natural protein antigens containing only one or a few epitopes and therefore unable to effectively cross-link Ig molecules on specific B cells. For example, keyhole limpet hemocyanin (KLH) immune complexes can be taken up and processed by all CR2-bearing B cells, regardless of their antigen specificity. KLH immune complexes taken up this way by non-specific B cells were shown to be presented to KLH-specific, MHC class II Th cells. CD23 may also serve as a ligand for CD21 [3].Synonyms: C3DR, C3d receptor, CR2, Complement C3d receptor, Complement receptor type 2, Dendritic Cell Marker, EBV Receptor, Epstein-Barr virus receptor
Gene ID 1380
NCBI Accession NP_001006659
UniProt P20023
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer 0.01 M sodium phosphate, 0.15 M NaCl, pH 7.3, 0.2 % BSA, 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C. Fluorochrome labelled product is photosensitive and should be protected from light.
Supplier Images
image for anti-Complement Component (3d/Epstein Barr Virus) Receptor 2 (CR2) antibody (FITC) (ABIN1106066) anti-Complement Component (3d/Epstein Barr Virus) Receptor 2 (CR2) antibody (FITC)
Background publications Hoffmann, Reichhart, Hetru: "Innate immunity in higher insects." in: Current opinion in immunology, Vol. 8, Issue 1, pp. 8-13, 1996 (PubMed).

Timens, Boes, Vos, Poppema: "Tissue distribution of the C3d/EBV-receptor: CD21 monoclonal antibodies reactive with a variety of epithelial cells, medullary thymocytes, and peripheral T-cells." in: Histochemistry, Vol. 95, Issue 6, pp. 605-11, 1991 (PubMed).

Ahearn, Fearon: "Structure and function of the complement receptors, CR1 (CD35) and CR2 (CD21)." in: Advances in immunology, Vol. 46, pp. 183-219, 1989 (PubMed).