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  • 产品名称：anti-CD59antibody(CD59)(FITC)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-CD59antibody(CD59)(FITC)
详情介绍：
Clone NaM172-2B5
Isotype IgG1
Specificity Clone NaM172-2B5 recognizes the human CD59 antigen. Other species not tested.
Purification Affinity chromatography
Alternative Name CD59 (CD59 Antibody Abstract)
Background CD59 can be found in body fluids including blood plasma, saliva, amniotic fluid, seminal fluid, and urine. It is expressed as a 18-25 kD glycoprotein (in lymphocytes)anchored in the membrane by GPI tail. Since CD59 is well known membrane-associated complement regulator protein, like CD55, and present on all blood cells, anti-CD55 and anti-CD59 appear to be the most effective Mabs to detect very minor negative cell subsets (less than 1 % on erythrocytes or less than 5 % on PMN leukocytes.Synonyms: 20 kDa homologous restriction factor, HRF-20, HRF20, MAC-IP, MAC-inhibitory protein, MACIF, MEM43 antigen, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, Protectin
Gene ID 966
NCBI Accession NP_000602
UniProt P13987
Research Area Cardiovascular, Atherosclerosis, Hematopoietic Progenitors, Tyrosine Kinases, Innate Immunity, CD Antigens, Surface Receptors of Immune Cells
Pathways Complement System
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer 0.01 M sodium phosphate, 0.15 M NaCl, pH 7.3, 0.2 % BSA, 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C. Fluorochrome labelled product is photosensitive and should be protected from light.
Supplier Images
image for anti-CD59 antibody (CD59) (FITC) (ABIN1106481) anti-CD59 (CD59) antibody (FITC)
Background publications Kinoshita, Inoue, Takeda: "Defective glycosyl phosphatidylinositol anchor synthesis and paroxysmal nocturnal hemoglobinuria." in: Advances in immunology, Vol. 60, pp. 57-103, 1996 (PubMed).

Socié, Mary, de Gramont, Rio, Leporrier, Rose, Heudier, Rochant, Cahn, Gluckman: "Paroxysmal nocturnal haemoglobinuria: long-term follow-up and prognostic factors. French Society of Haematology." in: Lancet, Vol. 348, Issue 9027, pp. 573-7, 1996 (PubMed).

Hall, Rosse: "The use of monoclonal antibodies and flow cytometry in the diagnosis of paroxysmal nocturnal hemoglobinuria." in: Blood, Vol. 87, Issue 12, pp. 5332-40, 1996 (PubMed).

Iwamoto, Kawaguchi, Nagakura, Hidaka, Horikawa, Kagimoto, Takatsuki, Nakakuma: "Markedly high population of affected reticulocytes negative for decay-accelerating factor and CD59 in paroxysmal nocturnal hemoglobinuria." in: Blood, Vol. 85, Issue 8, pp. 2228-32, 1995 (PubMed).

Yeh, Rosse: "Paroxysmal nocturnal hemoglobinuria and the glycosylphosphatidylinositol anchor." in: The Journal of clinical investigation, Vol. 93, Issue 6, pp. 2305-10, 1994 (PubMed).

Rotoli, Luzzatto: "Paroxysmal nocturnal haemoglobinuria." in: Baillière's clinical haematology, Vol. 2, Issue 1, pp. 113-38, 1989 (PubMed).