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  • 产品名称：anti-CD43antibody(Sialophorin)(FITC)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-CD43antibody(Sialophorin)(FITC)
详情介绍：
Clone MT1
Isotype IgG1
Specificity Clone MT1, specific for CD43, produces mouse IgG1 immunoglobulins reactive with a 95-115 kDa highly sialated glycoprotein. Clone MT1 antibody is used to identify B cell lines and myeloma cells. It may be used in the diagnosis of chronic lymphocytic leukemias (CLL), as an alternative to CD5. The antigen detected by MT1 is the only marker expressed on neoplasms of the very early precursor cells. In immunohistochemistry it reacts with T cells, macrophages, myeloid cells and B cells (weak). It is used for the typing of lymphomas in paraffin sections [3-5].
Purification Affinity chromatography
Alternative Name CD43 / Leukosialin (SPN Antibody Abstract)
Background CD43 antigen is expressed on all T cells, NK cells, myeloid cells and monocytes as well as on CD5 positive mature B cells. It is also present on all immature hematopoietic cells in the bone marrow [1]. The antigen is deficient in patients with Wiskott-Aldrich syndrome. A soluble form of CD43 is present in human serum [2]. CD43 may function as an adhesion molecule via interaction with CD54 although this has not been definitely established. It may also inhibit leucocyte interactions with other cells [6]. The antigen is involved in the activation of T-cells, B cells, NK cells and monocytes [5]. The membrane proximal portion of the cytoplasmic domain mediates an association with the cytoskeleton [1].Synonyms: Galactoglycoprotein, Leukocyte sialoglycoprotein, SPN, Sialophorin
Gene ID 6693
NCBI Accession NP_001025459
UniProt P16150
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways Regulation of Leukocyte Mediated Immunity
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer 0.01 M sodium phosphate, 0.15 M NaCl, pH 7.3, 0.2 % BSA, 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C. Fluorochrome labelled product is photosensitive and should be protected from light.
Supplier Images
image for anti-CD43 antibody (Sialophorin) (FITC) (ABIN1106375) anti-Sialophorin (SPN) antibody (FITC)
Background publications Poppema, Hollema, Visser, Vos: "Monoclonal antibodies (MT1, MT2, MB1, MB2, MB3) reactive with leukocyte subsets in paraffin-embedded tissue sections." in: The American journal of pathology, Vol. 127, Issue 3, pp. 418-29, 1987 (PubMed).