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  • 产品名称：anti-CD209Molecule(CD209)antibody(PE)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-CD209Molecule(CD209)antibody(PE)
详情介绍：
Immunogen Immature myeloid monocyte-derived dendritic cells (MDDCs). Spleen cells from immunised Balb/c mice were fused with cells of the Mouse SP2/0-Ag14 myeloma cell line.
Clone MR-1
Isotype IgG1
Specificity This antibody recognises human DC-specific ICAM-3 grabbing nonintegrin (DC-SIGN), a 45 kDa C-type lectin that binds ICAM-3 which is also known as CD209. Clone MR-1 is reported to partially block the functional activity of DC-SIGN. We recommend the use of SM2219LE for this purpose.
Purification Affinity Chromatography on Protein G.
Alternative Name CD209 / DC-SIGN (CD209 Antibody Abstract)
Background CD209 is primarily expressed on a population of immature dendritic cells in peripheral tissues and on immature myeloid monocyte-derived DC's in vitro. CD209 is involved in dendritic cell (DC) migration and the initial interaction between DC's and naive T lymphocytes. CD209 also binds HIV-1 gp120 and plays a key role in the dissemination of HIV-1 by DC's.Synonyms: C-type lectin domain family 4 member L, CLEC4L, DC-SIGN1, DCSIGN, DCSIGN1, Dendritic Cell Marker, Dendritic cell-specific ICAM-3-grabbing non-integrin 1
Gene ID 9606
UniProt Q9NNX6
Research Area CD Antigens
Application Notes Flow Cytometry (Neat-1/10): Use 10 μL of the suggested working dilution to label 10^6 cells in 100 μL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore with 1 mL distilled water
Concentration 0.1 mg/mL
Buffer PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice This product is photosensitive and should be protected from light
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C. DO NOT FREEZE!
Background publications Relloso, Puig-Kröger, Pello, Rodríguez-Fernández, de la Rosa, Longo, Navarro, Muñoz-Fernández, Sánchez-Mateos, Corbí: "DC-SIGN (CD209) expression is IL-4 dependent and is negatively regulated by IFN, TGF-beta, and anti-inflammatory agents." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 6, pp. 2634-43, 2002 (PubMed).

Melero, Gabari, Corbí, Relloso, Mazzolini, Schmitz, Rodriguez-Calvillo, Tirapu, Camafeita, Albar, Prieto: "An anti-ICAM-2 (CD102) monoclonal antibody induces immune-mediated regressions of transplanted ICAM-2-negative colon carcinomas." in: Cancer research, Vol. 62, Issue 11, pp. 3167-74, 2002 (PubMed).