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  • 产品名称：anti-FCER1Aantibody(FcFragmentofIgE,HighAffinityI,ReceptorFor,alphaPolypeptide)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-FCER1Aantibody(FcFragmentofIgE,HighAffinityI,ReceptorFor,alphaPolypeptide)(PE)
详情介绍：
Immunogen Spleen cells from immunised Balb/c mice were fused with cells of the Sp2/0-Ag14 myeloma cell line.
Clone 9-00E-001
Isotype IgG2b
Specificity This antibody recognises the high affinity Fc receptor for IgE (Fc epsilon R1), which plays a central role in the IgE-mediated allergic response. Clone 9E1 specifically recognises the extracellular D1 domain of the Fc epsilon R1 alpha chain.
Purification Affinity Chromatography on Protein G.
Alternative Name FCER1A (FCER1A Antibody Abstract)
Background Fc epsilon R1 consists of four subunits, a high affinity IgE binding alpha subunit, a beta chain and two di-sulphide linked gamma subunits. Fc epsilon R1 is primarily expressed on mast cells and basophils but expression of Fc epsilon R1 has also been reported on monocytes, Langerhans cells and dendritic cells from patients with atopic diseases.Synonyms: FCE1A, Fc-epsilon RI-alpha, FcERI, High affinity immunoglobulin epsilon receptor subunit alpha, IgE Fc receptor subunit alpha
Gene ID 2205
NCBI Accession NP_001992
UniProt P12319
Pathways Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
Application Notes Flow Cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore with 1.0 mL distilled water.
Concentration 0.1 mg/mL
Buffer PBS containing 0.09 % Sodium Azide as preservative and 1 % BSA and 5 % sucrose as stabilzers.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice This product is photosensitive and should be protected from light
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C. DO NOT FREEZE!
Background publications Vangelista, Cesco-Gaspere, Lorenzi, Burrone: "A minimal receptor-Ig chimera of human FcepsilonRI alpha-chain efficiently binds secretory and membrane IgE." in: Protein engineering, Vol. 15, Issue 1, pp. 51-7, 2002 (PubMed).

Vangelista, Cesco-Gaspere, Lamba, Burrone: "Efficient folding of the FcepsilonRI alpha-chain membrane-proximal domain D2 depends on the presence of the N-terminal domain D1." in: Journal of molecular biology, Vol. 322, Issue 4, pp. 815-25, 2002 (PubMed).