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  • 产品名称：anti-IL6STantibody(Interleukin6SignalTransducer(Gp130,OncostatinMReceptor))(PE)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-IL6STantibody(Interleukin6SignalTransducer(Gp130,OncostatinMReceptor))(PE)
详情介绍：
Immunogen Mouse CD130 transfected cells
Clone RMb1
Isotype IgG2a
Cross-Reactivity (Details) Species reactivity (tested):Mouse
Alternative Name CD130 / IL6ST (IL6ST Antibody Abstract)
Background The interleukin-6 (IL-6) cytokine family, including IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), and B-cell stimulatory factor 3, are also known as gp130 cytokines because they all share gp130 as a common transducer protein within their functional receptor complexes. In the case of IL-6, binding of the ligand to its specific a-receptor (IL-6Ra/CD126) induces dimerization of gp130, activation of the gp130-associated Janus kinases Jak1, Jak2 and Tyk2 and phosphorylation of gp130 at cytoplasmic tyrosine residues. These phosphotyrosines serve as docking sites for SH2-domain-containing proteins such as STAT1, STAT3, the protein tyrosine phosphatase SHP2 and the suppressor of cytokine signalling 3 (SOCS3). The subsequently tyrosine phosphorylated STAT homo- or heterodimers translocate to the nucleus where they bind to enhancer sequences of IL-6-inducible genes. Both IL-6Ra and gp130 have soluble forms. Although soluble gp130 inhibits the effect of IL-6, the soluble IL-6Ra promotes the effect of IL-6.Synonyms: IL-6R-beta, IL6 receptor beta, Interleukin-6 receptor subunit beta
Gene ID 10090
UniProt Q00560
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways JAK-STAT Signaling, Cellular Glucan Metabolic Process, Autophagy, Smooth Muscle Cell Migration
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer 50 tests in 1 mLvolume of PBS, 0.09 % NaN3, 1 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 2 - 8 °C.
Supplier Images
Flow Cytometry (FACS) image for anti-IL6ST antibody (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor)) (PE) (ABIN1105853) anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) antibody (PE)
Background publications Kubota, Avarbock, Brinster: "Growth factors essential for self-renewal and expansion of mouse spermatogonial stem cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 47, pp. 16489-94, 2004 (PubMed).

Richardson, Starr, Angus, Hilton: "A somatic cell genetic system for dissecting hemopoietic cytokine signal transduction." in: The Journal of biological chemistry, Vol. 277, Issue 28, pp. 25624-30, 2002 (PubMed).

Matsuda, Hirano: "Establishment of the ELISA for murine soluble gp130, a signal transducer for the IL-6 family cytokine, and its detection in the ascitic fluids of tumor-bearing mice." in: Biochemical and biophysical research communications, Vol. 202, Issue 1, pp. 637-42, 1994 (PubMed).

Matsuda, Yamanaka, Hirano: "Interleukin-6-induced tyrosine phosphorylation of multiple proteins in murine hematopoietic lineage cells." in: Biochemical and biophysical research communications, Vol. 200, Issue 2, pp. 821-8, 1994 (PubMed).

Hirano, Matsuda, Nakajima: "Signal transduction through gp130 that is shared among the receptors for the interleukin 6 related cytokine subfamily." in: Stem cells (Dayton, Ohio), Vol. 12, Issue 3, pp. 262-77, 1994 (PubMed).

Yin, Taga, Tsang, Yasukawa, Kishimoto, Yang: "Involvement of IL-6 signal transducer gp130 in IL-11-mediated signal transduction." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 151, Issue 5, pp. 2555-61, 1993 (PubMed).