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  • 产品名称：anti-TransferrinReceptor(p90,CD71)(TFRC)antibody(FITC)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-TransferrinReceptor(p90,CD71)(TFRC)antibody(FITC)
详情介绍：
Immunogen Human myeloma cell line (RPMI8226)
Clone WK7
Isotype IgG1
Purification Protein A agarose
Alternative Name CD71 / TFRC (TFRC Antibody Abstract)
Background CD71 is a homodimeric type II transmembrane glycoprotein consisting of two disulfide-bonded 95 kDa chains. CD71 is the transferrin receptor (TfR). The CD71 binds iron saturated holo-transferrin on the cell surface and is internalized and transported to early sorting endosomes, where the complexed iron is rapidly separated from transferrin. Subsequently, the CD71-transferrin complex accumulates within recycling endosomes and then recycles to the plasma membrane. On the cell surface, iron-free apotransferrin has negligible affinity for CD71, and is released from the cell, ready to begin a new cycle. CD 71 is expressed on activated B and T cells, macrophages, reticulocytes, erythroid precursors, and malignant tissues. Particularly high expression of CD71 is reported in the reticulocytes and erythroid series, reflecting the requirement for iron in hemoglobin. CD71 expression is upregulated on immature proliferating cells and low levels on resting mature lymphocytes. In addition to this general function, CD71 appears to play a costimulatory role in T cell activation and receptor for IgA1 antibodies.Synonyms: TfR1, Transferrin receptor protein 1, p90
Gene ID 9606
UniProt P02786
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways Transition Metal Ion Homeostasis
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 1 % BSA and 0.09 % NaN3
Storage 4 °C
Storage Comment Store at 2-8 °C.
Supplier Images
Flow Cytometry (FACS) image for anti-Transferrin Receptor (p90, CD71) (TFRC) antibody (FITC) (ABIN1449272) anti-Transferrin Receptor (p90, CD71) (TFRC) antibody (FITC)
Flow Cytometry (FACS) image for anti-Transferrin Receptor (p90, CD71) (TFRC) antibody (FITC) (ABIN1449272) anti-Transferrin Receptor (p90, CD71) (TFRC) antibody (FITC) (Image 2)
Background publications Casey, Di Jeso, Rao, Klausner, Harford: "Two genetic loci participate in the regulation by iron of the gene for the human transferrin receptor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 85, Issue 6, pp. 1787-91, 1988 (PubMed).

Schneider, Owen, Banville, Williams: "Primary structure of human transferrin receptor deduced from the mRNA sequence." in: Nature, Vol. 311, Issue 5987, pp. 675-8, 1984 (PubMed).

Sutherland, Delia, Schneider, Newman, Kemshead, Greaves: "Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 78, Issue 7, pp. 4515-9, 1981 (PubMed).