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  • 产品名称：anti-TEKantibody(TEKTyrosineKinase,Endothelial)(Biotin)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-TEKantibody(TEKTyrosineKinase,Endothelial)(Biotin)
详情介绍：
Immunogen Recombinant human soluble CD202b / TIE-2 protein
Clone Cl-16
Isotype IgG1
Specificity The unconjugated monoclonal antibody will detect native human TIE-2 /TEK in ELISA experiments and on the surface of different human cell types.
Purification Protein G purified
Alternative Name CD202b / TEK (TEK Antibody Abstract)
Background TIE2 (tyrosine kinase with Ig and EGF homology domains 2) is expressed almost exclusively in endothelial cells in mice, rats and humans. This receptor possesses a unique extracellular domain containing two immunoglobulin like loops separated by three epidermal growth factor like repeats that are connected to three fibronectin type III like repeats. The ligand for the receptor is Angiopoietin 1. Defects in TIE2 are associated with inherited venous malformations, the TIE2 signaling pathway appears to be critical for endothelial cell smooth muscle cell communication in venous morphogenesis.Synonyms: Angiopoietin-1 receptor, TIE-2, TIE2, Tunica interna endothelial cell kinase, Tyrosine-protein kinase receptor TEK, Tyrosine-protein kinase receptor TIE-2, p140 TEK
Gene ID 7010
NCBI Accession NP_000450
UniProt Q02763
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways RTK Signaling, Growth Factor Binding
Application Notes Western Blot. ELISA. FACS analysis and cell sorting: 2 - 5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore to a concentration of 0.1-1.0 mg/mL with sterile water. Centrifuge vial prior to opening
Buffer PBS, 50x BSA, 0.02 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at -20 °C. Following reconstitution store undiluted at 2-8 °C for two weeks or (in aliquots) at -20 °C for longer.
Background publications Van Hoof, Dormeyer, Braam, Passier, Monshouwer-Kloots, Ward-van Oostwaard, Heck, Krijgsveld, Mummery: "Identification of cell surface proteins for antibody-based selection of human embryonic stem cell-derived cardiomyocytes." in: Journal of proteome research, Vol. 9, Issue 3, pp. 1610-8, 2010 (PubMed).

Harris, Reusch, Barleon, Hang, Dobbs, Marme: "Soluble Tie2 and Flt1 extracellular domains in serum of patients with renal cancer and response to antiangiogenic therapy." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 7, Issue 7, pp. 1992-7, 2001 (PubMed).

Partanen, Dumont: "Functions of Tie1 and Tie2 receptor tyrosine kinases in vascular development." in: Current topics in microbiology and immunology, Vol. 237, Issue 4, pp. 159-72, 1999 (PubMed).

Procopio, Pelavin, Lee, Yeilding: "Angiopoietin-1 and -2 coiled coil domains mediate distinct homo-oligomerization patterns, but fibrinogen-like domains mediate ligand activity." in: The Journal of biological chemistry, Vol. 274, Issue 42, pp. 30196-201, 1999 (PubMed).